ZBTB16

  • Official Full Name

    zinc finger and BTB domain containing 16

  • Overview

    This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL). Alternate transcriptional splice variants have been characterized.

  • Synonyms

    ZBTB16;zinc finger and BTB domain containing 16;zinc finger protein 145 (Kruppel like, expressed in promyelocytic leukemia) , ZNF145;zinc finger and BTB domain-containing protein 16;PLZF;zinc finger protein PLZF;zinc finger protein 145 (Kruppel-like, expressed in promyelocytic leukemia);ZNF145

Recombinant Proteins

  • Human
  • Rhesus macaque
  • Mouse
  • E.coli
  • Mammalian Cells
  • HEK293
  • His
  • Non
  • Avi
  • Fc
  • DDK
  • Myc
  • Flag
Cat.# Product name Source (Host) Species Tag Protein Length Price
ZBTB16-3639H Recombinant Human ZBTB16 protein, His-tagged E.coli Human His 394-667 aa
ZBTB16-5253R Recombinant Rhesus monkey ZBTB16 Protein, His-tagged Mammalian Cells Rhesus macaque His
ZBTB16-741HCL Recombinant Human ZBTB16 lysate HEK293 Human Non
ZBTB16-001H Recombinant Human ZBTB16 Protein, His tagged E.coli Human His 1-254aa
ZBTB16-2383H Recombinant Human ZBTB16 Protein, His (Fc)-Avi-tagged HEK293 Human Avi&Fc&His
ZBTB16-2383H-B Recombinant Human ZBTB16 Protein Pre-coupled Magnetic Beads HEK293 Human
ZBTB16-5066R Recombinant Rhesus Macaque ZBTB16 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
ZBTB16-5066R-B Recombinant Rhesus Macaque ZBTB16 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
ZBTB16-5544H Recombinant Human ZBTB16 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
Zbtb16-7049M Recombinant Mouse Zbtb16 Protein, Myc/DDK-tagged HEK293 Mouse DDK&Myc
ZBTB16-706HFL Recombinant Full Length Human ZBTB16 Protein, C-Flag-tagged Mammalian Cells Human Flag Full L.

    Involved Pathway

    ZBTB16 involved in several pathways and played different roles in them. We selected most pathways ZBTB16 participated on our site, such as Pathways in cancer,Transcriptional misregulation in cancer,Acute myeloid leukemia, which may be useful for your reference. Also, other proteins which involved in the same pathway with ZBTB16 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Pathways in cancer BAD,PTK2,BMP4,CYCS,WNT4,CKS2,LEF1,BCR,HDAC2,BIRC2
    Acute myeloid leukemia JUP,TCF7L2,EIF4EBP1,RPS6KB2,SPI1,PIK3CB,STAT5B,RUNX1T1,RELA,IKBKB
    Transcriptional misregulation in cancer IL1R2,IL-8,Aff1,FUT8,CCNT2,TSPAN7,HIST2H3C1,H3F3A,SUPT3H,HMGA2

    Protein Function

    ZBTB16 has several biochemical functions, for example, DNA binding,RNA polymerase II distal enhancer sequence-specific DNA binding,identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ZBTB16 itself. We selected most functions ZBTB16 had, and list some proteins which have the same functions with ZBTB16. You can find most of the proteins on our site.

    Function Related Protein
    protein domain specific binding PPP3R1,CHMP2A,NLRP1,RXRA,NEDD4,RQCD1,IRS2,ST13,ARL1,DVL2
    transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding GZF1,PROP1,BACH1,MSC,ARX,BACH2,PAX4
    DNA binding ZNF280C,HOXB7A,GLIS2,SETDB1A,ARID5B,HOPX,CRY1,ZNF560,SIX6,SIX1
    protein binding KLHL6,OPRK1,CASP14,ANK2,CD6,POC1B,GAPDH,TMEM106C,TRIM2,TRPC1
    identical protein binding TPCN2,MRAP2,AIRE,KIRRELA,UBQLN1,SNX16,VIL1,PPPDE2,PRDX1,PYDC3
    protein homodimerization activity EIF2AK1,CAMK2G,PRTFDC1,LDB1,TGFB2,PTPRE,USH2A,Anks6,TPD52L2,APOBEC3G
    metal ion binding ZKSCAN14,ZNF333,DDHD2,PMM1,MCM2,TATDN3,GNAL,PRDM8B,CSHL1,MORC4
    RNA polymerase II distal enhancer sequence-specific DNA binding CDX2,PAX4,NFE2L1,ARID3B,POU4F1,H2AFZ,ATF2,HNRNPC,NONO,NFKB1
    protein C-terminus binding TERF2,EFHC1,HIC2,KCNIP3,PEX12,ERCC6,MED12,DLG4,PCGF1,PPP2CB

    Interacting Protein

    ZBTB16 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ZBTB16 here. Most of them are supplied by our site. Hope this information will be useful for your research of ZBTB16.

    PML;EEF1A1;IL6;Hoxa1;TRAF2

    Resources

    Research Area

    Transcription Factors in the Akt Pathway
    Hematopoietic Stem Cell Markers
    Mesenchymal Stem Cell Transcription Factors
    gamma delta T Cells
    Natural Killer T (NKT) Cells

    References

    • Zheng, Y; Thomas, A; et al. Quantitative detection of human spermatogonia for optimization of spermatogonial stem cell culture. HUMAN REPRODUCTION 29:2497-2511(2014).
    • Pomerantz, RG; Mirvish, ED; et al. Novel approach to gene expression profiling in Sezary syndrome. BRITISH JOURNAL OF DERMATOLOGY 163:1090-1094(2010).

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