YWHAE

  • Official Full Name

    tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
  • Overview

    14-3-3 proteins are highly conserved proteins which play a role in both signal transduction and progression through the cell cycle by binding to and regulating several different proteins. 14-3-3 proteins activate tyrosine and tryptophan hydroxylases and protein kinase C. They mediate signal transduction by binding to phosphoserine containing proteins. There are at least 7 mammalian isoforms: alpha, beta, gamma, delta, epsilon, zeta, and eta. An eighth subtype, termed theta has been found in rat brain. The 14-3-3 proteins exists in vitro and in vivo as either homo- or heterodimers which interact via their N-terminal domains and are subject to phosphorylation by protein kinase C. 14-3-3 proteins are localized in the cytoplasm of neurons in the cerebral cortex and are axonally transported to the nerve terminals. They may be present at lower levels in various other eukaryotic tissues. Northern blot analysis has shown expression of the eta chain in cultured cell lines derived from various tumors.
  • Synonyms

    YWHAE;tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide;14-3-3 protein epsilon;14 3 3 epsilon;FLJ45465;14-3-3 epsilon;protein kinase C inhibitor protein-1;mitochondrial import stimulation factor L subunit

Recombinant Proteins

  • Human
  • Cynomolgus
  • Mouse
  • Chicken
  • Rat
  • E.coli
  • Mammalian Cells
  • Human
  • Insect Cells
  • HEK293
  • GST
  • His
  • Flag
  • Non
  • Avi
  • Fc
  • DDK
  • Myc
Cat.# Product name Source (Host) Species Tag Protein Length Price
YWHAE-878H Recombinant Human YWHAE protein(Met1-Gln255), GST-tagged E.coli Human GST 1-255 a.a.
YWHAE-2595H Recombinant Human YWHAE protein, His-tagged E.coli Human His 1-255 aa
YWHAE-237HFL Active Recombinant Full Length Human YWHAE Protein, C-Flag-tagged Mammalian Cells Human Flag Full L.
YWHAE-019H Recombinant Human YWHAE Protein, His-tagged E.coli Human His Full L.
YWHAE-1093C Recombinant Cynomolgus YWHAE Protein, His-tagged Mammalian Cells Cynomolgus His
YWHAE-10H Recombinant Human Tyrosine 3-monooxygenase/ Tryptophan 5-monooxygenase Activation Protein, Epsilon Polypeptide E.coli Human Non
YWHAE-1193M Recombinant Mouse YWHAE, GST-tagged Human Mouse His 1-255 a.a.
YWHAE-1367C Recombinant Chicken YWHAE Mammalian Cells Chicken His
YWHAE-137H Recombinant Human YWHAE Protein, His-tagged Insect Cells Human His
YWHAE-18683M Recombinant Mouse YWHAE Protein Mammalian Cells Mouse His
YWHAE-26003TH Recombinant Human YWHAE E.coli Human Non
YWHAE-26004TH Recombinant Human YWHAE E.coli Human Non Full L.
YWHAE-26006TH Recombinant Human YWHAE protein(Met1-Gln255) E.coli Human Non Met1-Gln255
YWHAE-4896H Recombinant Human Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Epsilon Polypeptide E.coli Human Non
YWHAE-4897H Recombinant Human Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Epsilon Polypeptide, GST-tagged E.coli Human GST
YWHAE-6638R Recombinant Rat YWHAE Protein Mammalian Cells Rat His
YWHAE-873H Recombinant Human YWHAE, None tagged E.coli Human Non 1-255 a.a.
YWHAE-888M Recombinant Mouse YWHAE protein(Met1-Gln255), GST-tagged E.coli Mouse GST Met1-Gln255
YWHAE-740HCL Recombinant Human YWHAE lysate HEK293 Human Non
YWHAE-10269M Recombinant Mouse YWHAE Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
YWHAE-10269M-B Recombinant Mouse YWHAE Protein Pre-coupled Magnetic Beads HEK293 Mouse
YWHAE-150H Recombinant Human YWHAE Protein, His-tagged E.coli Human His
YWHAE-2378H Recombinant Human YWHAE Protein, His (Fc)-Avi-tagged HEK293 Human Avi&Fc&His
YWHAE-2378H-B Recombinant Human YWHAE Protein Pre-coupled Magnetic Beads HEK293 Human
YWHAE-6294R Recombinant Rat YWHAE Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
YWHAE-6294R-B Recombinant Rat YWHAE Protein Pre-coupled Magnetic Beads HEK293 Rat
Ywhae-7040M Recombinant Mouse Ywhae Protein, Myc/DDK-tagged HEK293 Mouse DDK&Myc
YWHAE-7821H Recombinant Human YWHAE protein, His-tagged E.coli Human His 272aa(including fusion tag)
YWHAE-836C Recombinant Cynomolgus Monkey YWHAE Protein, His (Fc)-Avi-tagged HEK293 Cynomolgus Avi&Fc&His
YWHAE-836C-B Recombinant Cynomolgus Monkey YWHAE Protein Pre-coupled Magnetic Beads HEK293 Cynomolgus

    Involved Pathway

    YWHAE involved in several pathways and played different roles in them. We selected most pathways YWHAE participated on our site, such as Cell cycle,Oocyte meiosis,PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with YWHAE were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Oocyte meiosis CAMK2D,CPEB3,PPP3CC,PPP2R5A,PPP1CA,CUL1B,CPEB1,YWHAG,AURKA,CALML5
    PIK-Akt signaling pathway CRTC2,IFNA14,IFNA13,MDM2,PTEN,INS1,PRL,LAMA1,Il6ra,IBSP
    Neurotrophin signaling pathway RELA,PLCG1,NGFRAP1,CALM1,AKT1,RAPGEF1,MAPK8,CALM4,BAX,MATK
    Hippo signaling pathway CRB1,FZD2,YWHAH,STK3,PPP2R1A,TCF7L2,BMPR1B,WNT5B,FZD8,WNT1
    Viral carcinogenesis HIST1H2BK,HIST1H2BL,HIST1H2BG,SNW1,CCNA2,YWHAG,HIST2H4,HLA-G,HIST1H4I,PIK3CG
    Cell cycle CCNA1,SMAD3,CDK6,TUBGCP2,HDAC5,SMC1B,CEP63,CKAP5,MASTL,TGFB1A
    Epstein-Barr virus infection HLA-G,YWHAG,POLR2G,HDAC4,PRKACG,EIF2AK3,TRAF1,MAP2K4,GTF2E1,Fcer2a

    Protein Function

    YWHAE has several biochemical functions, for example, MHC class II protein complex binding,enzyme binding,histone deacetylase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by YWHAE itself. We selected most functions YWHAE had, and list some proteins which have the same functions with YWHAE. You can find most of the proteins on our site.

    Function Related Protein
    phosphoserine binding NEDD4,PIN1,YWHAB
    poly(A) RNA binding RG9MTD1,CANX,RPL3,TRA2A,ESF1,GRWD1,SF3B14,RPP25,FXR2,DIAPH1
    phosphoprotein binding FKBP4,GPRIN1,PAFAH1B1,SFN,IGF2R,MID2,ARR3,CACNB2,SAG,TRPV1
    enzyme binding NLRP1,ARRB2,NPM2,MAPK14,HSPA5,AKT1,H2AFX,SIRT3,TH,GOT2
    ion channel binding YWHAH,FKBP1B,USP10,FYN,RIMS1,KCND3,LYN,PRKCSH,KCNAB1,HSP90AB1
    MHC class II protein complex binding HLA-DMA,ATP1B1,HLA-DMB,MS4A1,ANXA11,HSP90AA1,PKM,CD74,HLA-DOA,HSP90AB1
    protein binding ISG15,RET,ARNT,UBXN4,PPP6R3,S100A11,ZNF205,SLA2,ATXN1,LTF
    ubiquitin protein ligase binding WFS1,HSPA1B,HSPA9,HSPA1A,DNAJA1,GABARAPL2,PRKACB,VCL,TMEM189,DNM1L
    potassium channel regulator activity KCNMB4,SGK2A,KCNIP4,SGK2B,DRD4,ADRB2,AMIGO1,KCNE1L,ARPP19A,KCNIP1

    Interacting Protein

    YWHAE has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with YWHAE here. Most of them are supplied by our site. Hope this information will be useful for your research of YWHAE.

    YWHAZ;LRRK2;HDAC4;ATXN1

    Resources

    References

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