YWHAE
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Official Full Name
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide -
Overview
14-3-3 proteins are highly conserved proteins which play a role in both signal transduction and progression through the cell cycle by binding to and regulating several different proteins. 14-3-3 proteins activate tyrosine and tryptophan hydroxylases and protein kinase C. They mediate signal transduction by binding to phosphoserine containing proteins. There are at least 7 mammalian isoforms: alpha, beta, gamma, delta, epsilon, zeta, and eta. An eighth subtype, termed theta has been found in rat brain. The 14-3-3 proteins exists in vitro and in vivo as either homo- or heterodimers which interact via their N-terminal domains and are subject to phosphorylation by protein kinase C. 14-3-3 proteins are localized in the cytoplasm of neurons in the cerebral cortex and are axonally transported to the nerve terminals. They may be present at lower levels in various other eukaryotic tissues. Northern blot analysis has shown expression of the eta chain in cultured cell lines derived from various tumors. -
Synonyms
YWHAE;tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide;14-3-3 protein epsilon;14 3 3 epsilon;FLJ45465;14-3-3 epsilon;protein kinase C inhibitor protein-1;mitochondrial import stimulation factor L subunit
Recombinant Proteins
- Human
- Cynomolgus
- Mouse
- Chicken
- Rat
- E.coli
- Mammalian Cells
- Human
- Insect Cells
- HEK293
- GST
- His
- Flag
- Non
- Avi
- Fc
- DDK
- Myc
Involved Pathway
YWHAE involved in several pathways and played different roles in them. We selected most pathways YWHAE participated on our site, such as Cell cycle,Oocyte meiosis,PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with YWHAE were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Neurotrophin signaling pathway | GAB1,PSEN1,PRDM4,Fasl,PSEN2,CAMK2D,IRS1,NGF,IKBKB,ARHGDIA |
| Hippo signaling pathway | SMAD1,ID1,YWHAH,GDF6,AJUBA,TGFB3,BMPR1A,PPP1CB,FZD1,TGFBR2 |
| Oocyte meiosis | YWHAB,CDC25C,PRKACBA,ANAPC13,REC8,PRKACAA,INS1,IGF1RB,YWHABL,YWHAG1 |
| PIK-Akt signaling pathway | COL4A1,NOS3,TRP53,IL7R,ANGPT1,ITGA10,Reln,PGF,G6PC3,FGF19 |
| Cell cycle | TMPO,GOLGA2,CDKN2D,NIPBL,NIPBLA,ACD,MASTL,CDK11B,NDEL1A,SPC25 |
| Viral carcinogenesis | MRPS18B,EGR3,PIK3R5,NFKB2,HDAC3,HIST1H2BL,PRKACG,MAPK3,PIK3CB,HDAC1 |
| Epstein-Barr virus infection | ENTPD1,HSPA1L,TYK2,POLR2H,SHFM1,CD38,MAPK11,MAP2K3,AKT2,PSMD4 |
Protein Function
YWHAE has several biochemical functions, for example, MHC class II protein complex binding,enzyme binding,histone deacetylase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by YWHAE itself. We selected most functions YWHAE had, and list some proteins which have the same functions with YWHAE. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| phosphoprotein binding | THRAP3,TBK1,URI1,FKBP4,PAFAH1B1,TRPV1,PIH1D1,SNCA,DPYSL3,SAG |
| phosphoserine binding | PIN1,NEDD4,YWHAB |
| poly(A) RNA binding | PURG,XRN2,YARS,RPS21,ZFP326,MRPS21,MRPS5,PUM1,RTN4,SAP18 |
| histone deacetylase binding | HIF1A,DNMT3B,NIPBL,KAT2A,SOD3,PRDM1,CEBPA,NRIP1,PARK2,CAMTA2 |
| protein heterodimerization activity | HIST1H47,EPAS1,CABYR,HIST1H2AG,HEXB,IRAK2,H3F3B.1,JDP2,BCL2L10,ROPN1B |
| protein binding | MICAL1,FAH,RBM15B,APOBEC3F,TMEM203,SUFU,CHRD,VEGFAA,RAB8A,CTLA4 |
| enzyme binding | RPS19BP1,PEX7,ERN1,UGT1A4,HLCS,CTNNB1,SIRT3,P4HB,MST1R,UGT1A9 |
| ion channel binding | GRINA,YWHAH,KCNB2,TRAPPC2,SLC14A2,HOMER1,FAM115C,CHERP,KCNE1L,ASPH |
| ubiquitin protein ligase binding | ACTG1,RIPK1,TRAF1,UBE2N,MID1,FLJ11011L,CUL5,STX8,PCBP2,TUBB |
Interacting Protein
YWHAE has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with YWHAE here. Most of them are supplied by our site. Hope this information will be useful for your research of YWHAE.
YWHAZ;LRRK2;HDAC4;ATXN1
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