YARS2
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Official Full Name
tyrosyl-tRNA synthetase 2, mitochondrial -
Overview
This gene encodes a mitochondrial protein that catalyzes the attachment of tyrosine to tRNA(Tyr). Mutations in this gene are associated with myopathy with lactic acidosis and sideroblastic anemia type 2 (MLASA2). -
Synonyms
YARS2;tyrosyl-tRNA synthetase 2, mitochondrial;tyrosyl-tRNA synthetase, mitochondrial;CGI 04;FLJ13995;mt TyrRS;tyrosine tRNA ligase 2;mitochondrial;Tyrosine tRNA ligase;Tyrosyl tRNA synthetase 2, mitochondrial;TYRRS;YARS 2;tyrosine tRNA ligase 2, mitochondrial;CGI-04;MLASA2;MT-TYRRS
Recombinant Proteins
- Human
- Rat
- Zebrafish
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| YARS2-3762H | Recombinant Human YARS2, GST-tagged | E.coli | Human | GST | 128-477aa | |
| YARS2-6624R | Recombinant Rat YARS2 Protein | Mammalian Cells | Rat | His |
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| YARS2-6783H | Recombinant Human Tyrosyl-tRNA Synthetase 2, Mitochondrial, His-tagged | E.coli | Human | His |
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| YARS2-7264Z | Recombinant Zebrafish YARS2 | Mammalian Cells | Zebrafish | His |
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| YARS2-1944HCL | Recombinant Human YARS2 cell lysate | Human | Non |
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| YARS2-4094H | Recombinant Human YARS2 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | Myc&DDK |
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| YARS2-601H | Recombinant Human YARS2 Protein, His-tagged | E.coli | Human | His | Met1-Phe219 |
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| Yars2-602M | Recombinant Mouse Yars2 Protein, His-tagged | E.coli | Mouse | His | Ala221-Leu472 |
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| YARS2-6280R | Recombinant Rat YARS2 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| YARS2-6280R-B | Recombinant Rat YARS2 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| Yars2-7028M | Recombinant Mouse Yars2 Protein, Myc/DDK-tagged | HEK293 | Mouse | Myc&DDK |
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Involved Pathway
YARS2 involved in several pathways and played different roles in them. We selected most pathways YARS2 participated on our site, such as Aminoacyl-tRNA biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with YARS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Aminoacyl-tRNA biosynthesis | PET112L,MARS2,IARS,DARS2,RARS2,PSTK,NARS2,QARS,WARS2,MADD |
Protein Function
YARS2 has several biochemical functions, for example, ATP binding,poly(A) RNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by YARS2 itself. We selected most functions YARS2 had, and list some proteins which have the same functions with YARS2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| tyrosine binding | ORA1,GPR143 |
| protein binding | TFAM,RPH3AL,RWDD1,FKBP1A,USP15,UPF3A,UBE2R2,IGFL1,TMEM8A,NOP10 |
| tRNA binding | EIF2AK4,IFIT5,METTL1,TRMT1,AARSD1,TYW5,XPO5,CTU2,NSUN2,EEF1A1 |
| ATP binding | PRKCHA,OASL2,ADCY3,NOL9,DARS2,VSIG8B,WARS2,SIK2,PIP4K2A,ACSL3 |
| tyrosine-tRNA ligase activity | MADD,YARS |
| protein homodimerization activity | PLOD1,ANXA1,KIAA0947,CPNE1,BAXA,ANXA6,NPPC,VIL1,ADIPOQ,SETMAR |
| poly(A) RNA binding | HIST1H4L,SMG1,RRP9,EMG1,PKN2,ZCCHC11,RPL24,RPL36,BAG4,CAST |
Interacting Protein
YARS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with YARS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of YARS2.
FAM9B;Ybx1;CDC20;USP49;pyrK;ssdna_dtdc;ICT1;MRPL50;L1RE1
Resources
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References
- Nakajima, J; Eminoglu, TF; et al. A novel homozygous YARS2 mutation causes severe myopathy, lactic acidosis, and sideroblastic anemia 2. JOURNAL OF HUMAN GENETICS 59:229-232(2014).
