WFS1
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Official Full Name
Wolfram syndrome 1 (wolframin) -
Overview
Wolfram syndrome protein (WFS1) is an 890 amino acid protein that contains a cytoplasmic N-terminal domain, followed by nine-transmembrane domains and a luminal C-terminal domain. WFS1 is predominantly localized to the endoplasmic reticulum (ER) and its -
Synonyms
WFS1;Wolfram syndrome 1 (wolframin);DFNA6, DFNA14, DFNA38;wolframin;DIDMOAD;WFS;WFRS;WFSL;FLJ51211
Recombinant Proteins
- Human
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- Mammalian cells
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
- Flag
Involved Pathway
WFS1 involved in several pathways and played different roles in them. We selected most pathways WFS1 participated on our site, such as Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with WFS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Protein processing in endoplasmic reticulum | HSPA4L,BCL2,PDIP5,EIF2AK2,YOD1,DAD1,EDEM1,EDEM2,RAD23AA,SSR3 |
Protein Function
WFS1 has several biochemical functions, for example, ATPase binding,protein binding,ubiquitin protein ligase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by WFS1 itself. We selected most functions WFS1 had, and list some proteins which have the same functions with WFS1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | FAM81B,DVL1,CLOCKA,MRPS27,IP6K2,EIF4H,IFIH1,ULK2,CMKLR1,KLRD1 |
| ubiquitin protein ligase binding | GABARAPL1,EGR2,USP2,SQSTM1,IKBKE,POU5F1,BLZF1,DBT,JAK1,UBE2R2 |
| ATPase binding | NR1H2,PEX26,ATPIF1A,GABARAPL2,ATP6V0A2B,ATXN3,ALDOB,PEX19,ATP6V0A1,FBL |
Interacting Protein
WFS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WFS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of WFS1.
TERF1;ITGB3BP;MAPK6;CFTR
Resources
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References
- Xu, R; Xia, B; et al. Expression and localization of Wolfram syndrome 1 gene in the developing rat pancreas. WORLD JOURNAL OF GASTROENTEROLOGY 15:5425-5431(2009).
- Boettcher, C; Brosig, B; et al. The subtle signs of Wolfram (DIDMOAD) syndrome: not all juvenile diabetes is type 1 diabetes. JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM 24:71-74(2011).
