VDR
-
Official Full Name
vitamin D (1,25- dihydroxyvitamin D3) receptor -
Overview
This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding different proteins. [provided by RefSeq, Feb 2011] -
Synonyms
VDR;vitamin D (1,25- dihydroxyvitamin D3) receptor;NR1I1;vitamin D3 receptor;1,25-dihydroxyvitamin D3 receptor;vitamin D nuclear receptor variant 1;nuclear receptor subfamily 1 group I member 1
Recombinant Proteins
- Human
- Mouse
- Rat
- Chicken
- E.coli
- Insect Cell
- Sf9 Insect Cell
- Insect Cells
- Mammalian Cell
- HEK293
- HEK293T
- His
- Non
- GST
- His&T7
- HIS
- Myc&DDK
- His&Fc&Avi
Involved Pathway
VDR involved in several pathways and played different roles in them. We selected most pathways VDR participated on our site, such as Endocrine and other factor-regulated calcium reabsorption,Mineral absorption,Tuberculosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with VDR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Tuberculosis | CASP10,TLR1,CD209B,TNFRSF1A,MAPK11,SPHK1,IFNA14,CASP9,CD14,TGFB3 |
| Endocrine and other factor-regulated calcium reabsorption | BDKRB2,KLK1B11,SLC8A1,KL,KLK1B3,PRKCG,ATP1A3,GNAS,PRKACG,KLK2 |
| Mineral absorption | TF,HEPH,SLC11A1,SLC8A1,MT1F,TRPM6,HMOX1,FTH1,MT1X,ATP1A2 |
Protein Function
VDR has several biochemical functions, for example, DNA binding,calcitriol binding,calcitriol receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by VDR itself. We selected most functions VDR had, and list some proteins which have the same functions with VDR. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcitriol receptor activity | VDRB,VDRA |
| lithocholic acid binding | VDRA |
| steroid hormone receptor activity | ESRRB,VDRB,NR3C2,RXRAA,NR4A3,NR5A1B,PAQR7,NR2C2,THRB,NR2F1A |
| contributes_to vitamin D response element binding | VDRB,VDRA,RXRA |
| calcitriol binding | VDRA |
| contributes_to transcription factor activity, sequence-specific DNA binding | FOXH1,GATA4,TAF10,SMAD2,SOX1B,VDRA,SOX19B,RXRA,VDRB,SOX1A |
| sequence-specific DNA binding | HOXA9,HIVEP2A,CREB3L3L,GZF1,TBX5A,NFIL3-4,HOXA6,GLI1,LHX2A,HOXA2B |
| DNA binding | ZFP28,AGFG1,RAD51AP1,SIX3B,NKX2.7,ZNF445,ZC3H3,SRRT,MLLT10,MXTX2 |
| retinoid X receptor binding | NCOA1,HMGA1,NCOR1,MED25,FUS,NR4A2,NRIP1,PPARG,RARB,RARG |
Interacting Protein
VDR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with VDR here. Most of them are supplied by our site. Hope this information will be useful for your research of VDR.
SNW1;RXRA;EP300;TP53;co1a1_human_vdr-site_dna-probe;PTPN3
Resources
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References
- Bizzaro, G; Shoenfeld, Y; et al. Vitamin D and autoimmune thyroid diseases: facts and unresolved questions. IMMUNOLOGIC RESEARCH 61:46-52(2015).
- Bizzaro, G; Shoenfeld, Y; et al. Vitamin D and thyroid autoimmune diseases: the known and the obscure. IMMUNOLOGIC RESEARCH 61:107-109(2015).
