VAC14
-
Official Full Name
Vac14 homolog (S. cerevisiae) -
Overview
The content of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) in endosomal membranes changes dynamically with;fission and fusion events that generate or absorb intracellular transport vesicles. VAC14 is a component of a;trimolecular complex that tightly regulates the level of PtdIns(3,5)P2. Other components of this complex are the;PtdIns(3,5)P2-synthesizing enzyme PIKFYVE (MIM 609414) and the PtdIns(3,5)P2 phosphatase FIG4 (MIM 609390). VAC14;functions as an activator of PIKFYVE (Sbrissa et al., 2007 (PubMed 17556371)). -
Synonyms
VAC14;Vac14 homolog (S. cerevisiae);Tax1 (human T cell leukemia virus type I) binding protein 2 , TAX1BP2;protein VAC14 homolog;ArPIKfyve;FLJ10305;FLJ36622;FLJ46582;MGC149815;MGC149816;OTTHUMP00000174908;Tax1 (human T cell leukemia virus type I) binding protein 1;Tax1 (human T cell leukemia virus type I) binding protein 2;Tax1 binding protein 2;Tax1-binding protein 2;TAX1BP2;TRX;VAC 14;Vac14 homolog;VAC14_HUMAN;Tax1 (human T-cell leukemia virus type I) binding protein 1;Tax1 (human T-cell leukemia virus type I) binding protein 2
Recombinant Proteins
- Zebrafish
- Mouse
- Chicken
- Human
- Rhesus macaque
- Rat
- Mammalian Cells
- E.coli
- Wheat Germ
- HEK293
- His
- Non
- GST
- Flag
- His&Fc&Avi
- Myc&DDK
Involved Pathway
VAC14 involved in several pathways and played different roles in them. We selected most pathways VAC14 participated on our site, such as HTLV-I infection,Viral carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with VAC14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| HTLV-I infection | HLA-A,FZD7,NFYB,PPP3CC,PRKACG,IL6,POLE4,SLC25A6,MAP3K1,HLA-B |
| Viral carcinogenesis | ACTN1,GTF2A1,HDAC7A,HLA-G,VDAC3,CCNE1,SKP2,RANBP1,SRF,TRAF1 |
Protein Function
VAC14 has several biochemical functions, for example, protein binding,receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by VAC14 itself. We selected most functions VAC14 had, and list some proteins which have the same functions with VAC14. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| receptor activity | TLR2,GRIN3B,CD200R4,TREML2,ADCYAP1R1,NLGN3A,AMHR2,NOTCH4,SEMA4D,RAMP3 |
| protein binding | SNRPB2,CXorf40A,MYC,ERLIN1,ORAI3,SMUG1,THRA,ABI1,JDP2,MPP6 |
Interacting Protein
VAC14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with VAC14 here. Most of them are supplied by our site. Hope this information will be useful for your research of VAC14.
PIKFYVE;NOS1;PPP2CA;CDRT4;9659
Resources
Related Services
Related Products
References
