UGP2
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Official Full Name
UDP-glucose pyrophosphorylase 2 -
Overview
The enzyme encoded by this gene is an important intermediary in mammalian carbohydrate interconversions. It transfers a glucose moiety from glucose-1-phosphate to MgUTP and forms UDP-glucose and MgPPi. In liver and muscle tissue, UDP-glucose is a direct precursor of glycogen; in lactating mammary gland it is converted to UDP-galactose which is then converted to lactose. The eukaryotic enzyme has no significant sequence similarity to the prokaryotic enzyme. Two transcript variants encoding different isoforms have been found for this gene. -
Synonyms
UGP2;UDP-glucose pyrophosphorylase 2;UTP--glucose-1-phosphate uridylyltransferase;pHC379;UDP glucose diphosphorylase;UDP glucose pyrophosphorylase 2;UDP glucose pyrophosphorylase;UDPG;UDPGP 2;UDPGP;UDPGP2;UGP 1;UGP 2;UGP1;UGPase 2;UGPase;UGPP 2;UGPP2;Uridyl diphosphate glucose pyrophosphorylase 2;UTP glucose 1 phosphate uridyltransferase;UTP glucose 1 phosphate uridylyltransferase 2;OTTHUMP00000159899;OTTHUMP00000214361;OTTHUMP00000214362;OTTHUMP00000214363;UDP-glucose diphosphorylase;UTP-glucose-1-phosphate uridyltransferase;UTP--glucose-1-phosphate uridylyltransferase 2;ur
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Chicken
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- Mammalian cells
- GST
- His
- Non
- His&Fc&Avi
- His&SUMO
- Myc&DDK
- Flag
Involved Pathway
UGP2 involved in several pathways and played different roles in them. We selected most pathways UGP2 participated on our site, such as Pentose and glucuronate interconversions,Galactose metabolism,Starch and sucrose metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with UGP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Galactose metabolism | B4GALT1,HKDC1,PFKP,HK1,HK3,aLA,G6PC3,PFKMB,GALE,AKR1B8 |
| Pentose and glucuronate interconversions | UGT1A6,ALDH2.1,ALDH2,UGT1AB,AKR1B1,UGT5G1,ALDH2.2,AKR1B1L,UGDH,DCXR |
| Metabolic pathways | UGT2A3,PSAT1,ABP1,CKMT1A,HPSE,EXTL3,GSTZ1,RRM2B,RDH8,KLF15 |
| Amino sugar and nucleotide sugar metabolism | GFPT1,GNPDA1,NAGK,UGP2A,CHIA,NANS,nanA,CYB5RL,UXS1,PMM1 |
| Starch and sucrose metabolism | G6PC2,UGP2A,TREH,HKDC1,HK1,Amy1,UGP2B,UGT1A9,UGT2A2,UGT2B7 |
Protein Function
UGP2 has several biochemical functions, for example, UTP:glucose-1-phosphate uridylyltransferase activity,glucose binding,identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UGP2 itself. We selected most functions UGP2 had, and list some proteins which have the same functions with UGP2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| UTP:glucose-1-phosphate uridylyltransferase activity | UGP2B,UGP2A |
| metal ion binding | ZNF10,OLA1,ZNF215,ZC3H8,RORAA,NTNG1,ZFP740,CYP4A12A,ZNF45,E4F1 |
| glucose binding | HK2,G6PDX,SLC2A3,HKDC1,PYGL,G6PD,SLC2A8,GYS1,HK3,HK1 |
| identical protein binding | CALHM1,NFKB1,CNTN2,DESI1,GBP5,SCAND1,GOT2B,GRB2,SCHIP1,TLE1 |
| protein binding | FAM107A,DACH1,FRA10AC1,VEGFA,HSP90AA1.1,GIMAP5,EGR2,RMND1,ADAP1,DNAJB4 |
Interacting Protein
UGP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UGP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of UGP2.
ARIH2;GLRX3;GRB2;PUF60;CBS;PCBP1;azr;TTN;nickel(2+)
Resources
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References
- Tan, GS; Lim, KH; et al. Novel Proteomic Biomarker Panel for Prediction of Aggressive Metastatic Hepatocellular Carcinoma Relapse in Surgically Resectable Patients. JOURNAL OF PROTEOME RESEARCH 13:4833-4846(2014).
- Wang, X; Ju, LG; et al. Histone H3K4 methyltransferase Mll1 regulates protein glycosylation and tunicamycin-induced apoptosis through transcriptional regulation. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1843:2592-2602(2014).
