UBE2J2
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Official Full Name
ubiquitin-conjugating enzyme E2, J2 -
Overview
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is located in the membrane of the endoplasmic reticulum. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined. -
Synonyms
UBE2J2;ubiquitin-conjugating enzyme E2, J2;ubiquitin conjugating enzyme E2, J2 (UBC6 homolog, yeast);ubiquitin-conjugating enzyme E2 J2;NCUBE2;Ubc6p;NCUBE-2;Non-canonical ubiquitin-conjugating enzyme 2;UB2J2_HUMAN;UBC6;UBC6 homolog;OTTHUMP00000001907;OTTHUMP00000002077;OTTHUMP00000002078;OTTHUMP00000220526;OTTHUMP00000220527;yeast UBC6 homolog;ubiquitin conjugating enzyme 6;ubiquitin conjugating enzyme E2, J2;ubiquitin-conjugating enzyme E2, J2 (UBC6 homolog, yeast);PRO2121
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| UBE2J2-244H | Recombinant Human UBE2J2 Protein, His-tagged | E.coli | Human | His | 124-224 a.a. |
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| UBE2J2-2485H | Recombinant Human Ubiquitin-Conjugating Enzyme E2, J2, His-tagged | E.coli | Human | His | 1-226aa |
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| UBE2J2-5621Z | Recombinant Zebrafish UBE2J2 | Mammalian Cell | Zebrafish | His |
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| UBE2J2-1870HCL | Recombinant Human UBE2J2 cell lysate | Human | Non |
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Involved Pathway
UBE2J2 involved in several pathways and played different roles in them. We selected most pathways UBE2J2 participated on our site, such as Adaptive Immune System,Antigen processing: Ubiquitination &,Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBE2J2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| presentation | UBA5,ASB7,CYBA,DTX3L,RNF220,GAN,DZIP3,UBR2,RNF19B,RBCK1 |
| Proteasome degradation | KLHL21,RBCK1,STUB1,UFL1,RNF14,CMTM2A,PJA1,DZIP3,RNF41,GAN |
| Adaptive Immune System | CYBB,UBE2V2,GRAP2B,CD207,SEC24A,KIFAP3,MOV10,HCST,TREML2,BTLA |
| Parkin-Ubiquitin Proteasomal System pathway | HSPA14,TUBA3E,TUBA1B,SIAH2,RNF19A,TUBA3D,HSPA7,TUBB7P,STUB1 |
| Antigen processing: Ubiquitination & | LRR1,ASB6,RNF220,ASB10,RNF25,TPP2,ASB13,RNF6,UBE2L6,RNF34 |
| Immune System | CSH1,TRIM41,PCBP2,CD96,KLRB1F,IRAK3,ARIH2,DUSP3B,USP18,TRIM50 |
| Parkinsons Disease Pathway | PARK7,SYT11,LRRK2,ATXN2 |
| Parkinsons disease | NDUFAB1,NDUFS5,NDUFA9,UQCRH,NDUFB3,mt-Atp8,NDUFA10,NDUFV2,NDUFB10,SLC18A1 |
| Class I MHC mediated antigen processing & | RNF111,HUWE1,UBE2V2,UBE2E3,DTX3L,RNF144B,ASB6,FBXO44,TRIM41,ASB18 |
Protein Function
UBE2J2 has several biochemical functions, for example, ATP binding,ubiquitin conjugating enzyme activity,ubiquitin protein ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UBE2J2 itself. We selected most functions UBE2J2 had, and list some proteins which have the same functions with UBE2J2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin protein ligase binding | DERL1,FZD5,KCNQ3,UBE2A,BAG5,PTPN22,TOLLIP,STUB1,BAG4,FZD8 |
| ubiquitin conjugating enzyme activity | UBE2L3,UBE2Q2,UBE2C,UBE2J1,CDC34,UBE2D2A,UBE2D3,UBE2G2,UBE2D1,UBE2QL1 |
| ubiquitin protein ligase activity | TRIM6,BTRC,RNF111,MED20,RAG1,TRAIP,UBE3A,RNF14,CDK8,TRIM3 |
| ATP binding | NEK4,GRK6,RAD51,DDX55,CSNK1A1,GRK5,DYRK3,ACTA1A,ACVR2A,RPS6KC1 |
Interacting Protein
UBE2J2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBE2J2 here. Most of them are supplied by our site. Hope this information will be useful for your research of UBE2J2.
PDE4DIP;FLJ10404;UBE1;ATP13A2
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References
- Lam, SY; Murphy, C; et al. The human ubiquitin conjugating enzyme UBE2J2 (Ubc6) is a substrate for proteasomal degradation. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 451:361-366(2014).
- van den Boomen, DJH; Timms, RT; et al. TMEM129 is a Derlin-1 associated ERAD E3 ligase essential for virus-induced degradation of MHC-I. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111:11425-11430(2014).
