UBE2F
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Official Full Name
ubiquitin-conjugating enzyme E2F (UBC6 homolog, C. elegans) -
Overview
Cullin-RING ligases (CRLs) comprise the largest subfamily of E3 ubiquitin ligases. In humans, six cullins (CUL1, -2, -3, -4A, -4B, and -5), two RBX-family RING proteins (RBX1 and -2), and hundreds of substrate receptors assemble into distinct CRLs that m -
Synonyms
UBE2F;ubiquitin-conjugating enzyme E2F (UBC6 homolog, C. elegans);NCE2;NEDD8 conjugating enzyme
Recombinant Proteins
- Human
- Zebrafish
- Chicken
- Mouse
- Rhesus macaque
- Rat
- E.coli
- Mammalian Cells
- HEK293
- Insect Cells
- GST
- His
- Non
- His&Strep
- DDK&Myc
- Avi&Fc&His
Involved Pathway
UBE2F involved in several pathways and played different roles in them. We selected most pathways UBE2F participated on our site, such as Adaptive Immune System,Antigen processing: Ubiquitination &,Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBE2F were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adaptive Immune System | KLRB1F,UBE2V1,SEC23A,LILRB3,RNF182,ERAP1,CTSC,CREB1,SLAMF6,HBEGF |
| Proteasome degradation | IWS1,RNF220,ASB7,ARIH2,UBE2V1,SPSB1,RNF138,RBCK1,TRIM69,TRAF7 |
| Immune System | HUWE1,ACTR1A,CLEC5A,NLRP4,CHST13,SIGLEC5,EIF4G2,CD200,Siglece,VPRBP |
| Integrated Breast Cancer Pathway | USP15,CYP19A1,DAG1,ERAL1,NOXA1,EDAR,USP16,GRN,SELK,LGALS13 |
| presentation | CTSS,ASB9,ASB3,TRIM9,SEC24A,FBXO44,ASB2,RBCK1,ERAP2,ASB6 |
| Ubiquitin mediated proteolysis | UBE2E2,MGRN1B,KEAP1,RHOBTB2,FBXW8,PRPF19,UBA7,PIAS4B,UBE1Y1,CBLB |
| Antigen processing: Ubiquitination & | RNF182,DTX3L,ATG7,HUWE1,LRR1,STUB1,TRIM9,VPRBP,WSB1,ASB11 |
| Class I MHC mediated antigen processing & | ASB6,GAN,MKRN1,SPSB4,TRIM9,RNF25,SEC61B,STUB1,TPP2,CYBA |
Protein Function
UBE2F has several biochemical functions, for example, ATP binding,NEDD8 transferase activity,ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UBE2F itself. We selected most functions UBE2F had, and list some proteins which have the same functions with UBE2F. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ligase activity | TRIM24,PET112L,TRIM17,UBE4B,WWP1,BIRC2,RFWD2,TMEM129,HERC2,MARCH11 |
| protein binding | ODF2,SF1,LAPTM5,SHISA5,PRKAR1A,Serpina1b,LMO2,TEKT1,PDIK1L,TRPC7 |
| NOT ubiquitin protein ligase activity | UBE2IA,UBE2M,UBE2I,VHLL,UBE2IB |
| ATP binding | HSPA7,SIK3,TLK1A,CCT6B,NEK7,HYOU1,RAD51B,ADCY3,ACSF2,CARKD |
| NEDD8 transferase activity | UBE2M,RBX1,RNF7 |
| NOT ubiquitin protein ligase binding | UBE2IA,UBE2I,UBE2M,UBE2IB |
Interacting Protein
UBE2F has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBE2F here. Most of them are supplied by our site. Hope this information will be useful for your research of UBE2F.
STAT1;TYK2;PRAME;UBA3;RNF34;WDR77;EIF2B4
Resources
Research Area
Ubiquitin-related Molecules in the Akt PathwayDNA Damage and Repair
E2 Ubiquitin/Ubl Conjugating Enzymes
Ubiquitin-like Modifiers (UBLs) and Regulators
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References
