UBA3
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Official Full Name
ubiquitin-like modifier activating enzyme 3 -
Overview
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. -
Synonyms
UBA3;ubiquitin-like modifier activating enzyme 3;UBE1C, ubiquitin activating enzyme E1C (homologous to yeast UBA3) , ubiquitin activating enzyme E1C (UBA3 homolog, yeast);NEDD8-activating enzyme E1 catalytic subunit;hUba3;ubiquitin activating enzym
Recombinant Proteins
- Cynomolgus
- Zebrafish
- Human
- Rhesus macaque
- Rat
- Wheat
- Mouse
- Mammalian Cells
- Sf9 Cells
- HEK293
- E.coli
- His
- GST
- Non
- DDK
- Myc
- Avi
- Fc
- KSI
Involved Pathway
UBA3 involved in several pathways and played different roles in them. We selected most pathways UBA3 participated on our site, such as Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBA3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ubiquitin mediated proteolysis | UBE2IB,SMURF2,UBE2D2L,UBE4B,BRCA1,CUL4B,NEDD4,CDC20,CUL4A,KEAP1 |
Protein Function
UBA3 has several biochemical functions, for example, ATP binding,NEDD8 activating enzyme activity,acid-amino acid ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UBA3 itself. We selected most functions UBA3 had, and list some proteins which have the same functions with UBA3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | TMEM171,MS4A3,INTS4,SMARCD3,CGA,ZFP259,ARPM1,EEF1G,CREB1,MALL |
| protein heterodimerization activity | KATNA1,HIST1H4H,BMP2,FLOT2,DMRTA2,CA,HIST2H2BE,HOMER2,HIST1H2AG,CAV2 |
| ligand-dependent nuclear receptor binding | SRA1,NCOA1,C1D,PPARGC1A,MED1,ARID1A,ISL1,SMARCD3,TADA3,JUND |
| acid-amino acid ligase activity | RAG1,TRIM25,RNF41 |
| ATP binding | RIPK1,OASL,PIP4K2B,DDX39B,MYLK2,MYH10,PFKMB,HIPK3B,SHPRH,TBK1 |
Interacting Protein
UBA3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBA3 here. Most of them are supplied by our site. Hope this information will be useful for your research of UBA3.
UBE2M;IMPA2;CPNE2;CUL1;FBXO11;CUL5;RAD23A;RAD23B;NEDD8;UIMC1;KDM1A;CHD3
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