TUBA1A
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Official Full Name
tubulin, alpha 1a -
Overview
Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulins. The genes encoding these microtubule constituents belong to the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes, which are highly conserved among species. This gene encodes alpha tubulin and is highly similar to mouse and rat Tuba1 gene. Northern blotting studies have shown that the gene expression is predominantly found in morphologically differentiated neurologic cells. This gene is one of three alpha-tubulin genes in a cluster on chromosome 12q. -
Synonyms
TUBA1A;tubulin, alpha 1a;tubulin alpha-1A chain;B ALPHA 1;FLJ25113;TUBA3;tubulin;alpha;brain specific;hum-a-tub1;hum-a-tub2;alpha-tubulin 3;tubulin, alpha 3;tubulin B-alpha-1;tubulin alpha-3 chain;tubulin, alpha, brain-specific;LIS3;B-ALP
Recombinant Proteins
- Human
- Mouse
- Rat
- Wheat Germ
- HEK293
- Mammalian Cell
- E.coli
- Mammalian cells
- In Vitro Cell Free System
- HEK293T
- GST
- Myc&DDK
- His
- Non
- Flag
- His&Fc&Avi
Involved Pathway
TUBA1A involved in several pathways and played different roles in them. We selected most pathways TUBA1A participated on our site, such as Phagosome,Gap junction,Pathogenic Escherichia coli infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with TUBA1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Gap junction | RAF1A,TUBA3A,PRKACB,TUBAL3,SRC,PRKCBA,ITPR3,GNAI3,EGFRA,GNA11 |
| Phagosome | CTSL1B,THBS3,HLA-DQB1,STX12,Pla2r1,CD209,ACTB2,THBS4A,NCF2,COLEC12 |
| Pathogenic Escherichia coli infection | ACTG1,TLR5,TUBB6,TUBB2B,TUBB7P,TUBA3E,ABL1,ACTB,TUBB1,ROCK2 |
Protein Function
TUBA1A has several biochemical functions, for example, GTP binding,GTPase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TUBA1A itself. We selected most functions TUBA1A had, and list some proteins which have the same functions with TUBA1A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTPase activity | GNGT2,GNAL,RAN,ARL3,RAB33B,GNAI2A,CDC42,DDX3X,RASL10A,RAB40AL |
| GTP binding | RAB2A,GNA12A,EEF1A1L2,RRAGCA,RHOGD,RAB22A,IRGM,RALB,FKBP4,SAR1AB |
| protein binding | C9orf43,TRIM25,ADAR,BEX5,SSX1,KPNA1,SEC23A,RBP4,BOLA1,DHX36 |
| structural molecule activity | RLN3B,LCE3D,SYNM,CLDNG,SEMG1,NES,CLTC,PRR9,CRYBB2,ISCA1 |
| protein domain specific binding | VAPA,YWHAE,HIST4H4,NDE1,ARFIP2A,MED12,TBL1X,ODF1,CENPJ,CASKIN1 |
| structural constituent of cytoskeleton | GFAP,ADD3,KRT17,ARPC3,AGRN,TUBB1,EPB42,TUBA8L4,TUBGCP2,KRT5 |
Interacting Protein
TUBA1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TUBA1A here. Most of them are supplied by our site. Hope this information will be useful for your research of TUBA1A.
EGFR;CYLD;LRRK2;HDAC6;HTRA2;MYO10;LTA;LGALS2;JUN;NCK1;NFKBIA
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References
- Romaniello, R; Arrigoni, F; et al. Mutations in alpha- and beta-tubulin encoding genes: Implications in brain malformations. BRAIN & DEVELOPMENT 37:273-280(2015).
- McMichael, G; Bainbridge, MN; et al. Whole-exome sequencing points to considerable genetic heterogeneity of cerebral palsy. MOLECULAR PSYCHIATRY 20:176-182(2015).
