TTN
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Official Full Name
titin -
Overview
This gene encodes a large abundant protein of striated muscle. The product of this gene is divided into two regions, a;N-terminal I-band and a C-terminal A-band. The I-band, which is the elastic part of the molecule, contains two regions;of tandem immunoglobulin domains on either side of a PEVK region that is rich in proline, glutamate, valine and;lysine. The A-band, which is thought to act as a protein-ruler, contains a mixture of immunoglobulin and fibronectin;repeats, and possesses kinase activity. An N-terminal Z-disc region and a C-terminal M-line region bind to the Z-line;and M-line of the sarcomere, respectively, so that a single titin molecule spans half the length of a sarcomere. Titin;also contains binding sites for muscle associated proteins so it serves as an adhesion template for the assembly of;contractile machinery in muscle cells. It has also been identified as a structural protein for chromosomes.;Alternative splicing of this gene results in multiple transcript variants. Considerable variability exists in the;I-band, the M-line and the Z-disc regions of titin. Variability in the I-band region contributes to the differences in;elasticity of different titin isoforms and, therefore, to the differences in elasticity of different muscle types.;Mutations in this gene are associated with familial hypertrophic cardiomyopathy 9, and autoantibodies to titin are;produced in patients with the autoimmune disease scleroderma. -
Synonyms
TTN;titin;cardiomyopathy, dilated 1G (autosomal dominant) , CMD1G;CMH9;CMPD4;FLJ32040;LGMD2J;MYLK5;TMD;connectin;rhabdomyosarcoma antigen MU-RMS-40.14;CMD1G;EOMFC;HMERF;FLJ26020;FLJ26409;FLJ34413;FLJ39564;FLJ43066;DKFZp451N061
Recombinant Proteins
- Human
- Mouse
- E.coli
- Wheat Germ
- His
- GST
- Non
- Myc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| TTN-1391H | Recombinant Human TTN Protein, His-tagged | E.coli | Human | His | 5398-5604 a.a. |
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| TTN-1780H | Recombinant Human TTN protein, His-tagged | E.coli | Human | His | Pro33779~Gln34025 |
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| TTN-25H | Recombinant Human TTN, GST-tagged | Wheat Germ | Human | GST&His |
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| TTN-26H | Recombinant Human TTN, GST-tagged | Wheat Germ | Human | GST |
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| TTN-27H | Recombinant Human TTN, GST-tagged | Wheat Germ | Human | GST |
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| TTN-705H | Recombinant Human Titin | E.coli | Human | Non |
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| TTN-301647H | Recombinant Human TTN protein, GST-tagged | E.coli | Human | GST | Met33738-Lys33969 |
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| TTN-3629H | Recombinant Human TTN protein, His&Myc-tagged | E.coli | Human | His&Myc | 14257-14543aa |
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| Ttn-507M | Recombinant Mouse Ttn Protein, His-tagged | E.coli | Mouse | His | Thr34750~Ser34990 |
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Involved Pathway
TTN involved in several pathways and played different roles in them. We selected most pathways TTN participated on our site, such as Hypertrophic cardiomyopathy (HCM),Dilated cardiomyopathy, which may be useful for your reference. Also, other proteins which involved in the same pathway with TTN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Dilated cardiomyopathy | TPM3,LMNA,DAG1,IGF1,CACNA2D2,DES,CACNG4,ITGA7,CACNA2D4,ACTC1 |
| Hypertrophic cardiomyopathy (HCM) | IL6,EMD,ITGA8,CACNB4,CACNG1,CACNA2D1,TNNC1,TPM1,ITGB3,ITGA10 |
Protein Function
TTN has several biochemical functions, for example, ATP binding,actin filament binding,actinin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TTN itself. We selected most functions TTN had, and list some proteins which have the same functions with TTN. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| telethonin binding | BMP10,CSRP3,MYOZ2,KCNE1 |
| calmodulin binding | MYH3,MYO7A,SLC9A1,PHKG2,CAMK2G,KCNH5,UPF3B,NOS1,PPP3CC,MKNK2B |
| calcium ion binding | BGLAP2,CALR,PCDH1G26,SYT4,PLCB2,SYT11,CASQ1,GSN,MYL9,CALB1 |
| protein tyrosine kinase activity | PDGFRB,BAZ1B,MAP3K11,FGFR4,BCR,INSR,MAP2K6,EPHA4B,FGFR1,DYRK4 |
| ATP binding | ATAD2B,BMPR1BB,DYNC1LI1,KIF6,EIF4A2,NOD1,AGK,Ckmm,TOP2A,NLRP12 |
| protein serine/threonine kinase activity | MAPK14B,DYRK3,TGFBR1A,DYRK2,ROCK2A,VPRBP,TAOK1,STK19,PRKCBA,MAPK11 |
| structural constituent of muscle | MYBPC3,MYOM1,TPM2,TPM1,MYL1,ACTN3,JPH1,PLEC,MYBPC1,MYBPC2 |
| protein kinase binding | MAP3K12,HDAC7A,CDKN2C,SPAG16,TOM1L1,PLCG1,STK11IP,TPCN2,PTK2,SPRY2 |
| actin filament binding | MYH11,WIPF2,MYO10,TRPV4,FSCN2A,FMNL1,FLNA,MYO6,ADSSL1,FSCN1A |
Interacting Protein
TTN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TTN here. Most of them are supplied by our site. Hope this information will be useful for your research of TTN.
Resources
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References
- Matsumoto, Y; Zhang, Q; et al. Trimeric Tn Antigen on Syndecan 1 Produced by ppGalNAc-T13 Enhances Cancer Metastasis via a Complex Formation with Integrin alpha 5 beta 1 and Matrix Metalloproteinase 9. JOURNAL OF BIOLOGICAL CHEMISTRY 288:24264-24276(2013).
- Cutino-Avila, B; Cunill-Semanat, E; et al. Synthesis of Tetanus Toxoid-Sepharose CL 4B derivatives by Rational Design. 5TH LATIN AMERICAN CONGRESS ON BIOMEDICAL ENGINEERING (CLAIB 2011): SUSTAINABLE TECHNOLOGIES FOR THE HEALTH OF ALL, PTS 1 AND 2 33:160-163(2013).
