TSEN2
-
Official Full Name
tRNA splicing endonuclease 2 homolog (S. cerevisiae) -
Overview
This gene encodes one of the subunits of the tRNA splicing endonuclease. This endonuclease catalyzes the first step in RNA splicing which is the removal of introns. Mutations in this gene have been associated with pontocerebellar hypoplasia type 2. A pseudogene has been identified on chromosome 4. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
TSEN2;tRNA splicing endonuclease 2 homolog (S. cerevisiae);tRNA splicing endonuclease 2 homolog (SEN2, S. cerevisiae);tRNA-splicing endonuclease subunit Sen2;MGC2776;SEN2;SEN2L;HsSen2;MGC4440;tRNA intron endonuclease Sen2;tRNA splicing endonuclease subunit Sen2;TSEN 2;tRNA-intron endonuclease Sen2;PCH2B
Recombinant Proteins
- Mouse
- Chicken
- Zebrafish
- Rat
- Human
- Mammalian Cell
- HEK293
- HEK293T
- His
- Non
- Myc&DDK
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| TSEN2-17480M | Recombinant Mouse TSEN2 Protein | Mammalian Cell | Mouse | His |
|
|
| TSEN2-2307C | Recombinant Chicken TSEN2 | Mammalian Cell | Chicken | His |
|
|
| TSEN2-4533Z | Recombinant Zebrafish TSEN2 | Mammalian Cell | Zebrafish | His |
|
|
| TSEN2-6313R | Recombinant Rat TSEN2 Protein | Mammalian Cell | Rat | His |
|
|
| TSEN2-1843HCL | Recombinant Human TSEN2 cell lysate | Human | Non |
|
||
| TSEN2-2803H | Recombinant Human TSEN2 Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
|
|
| TSEN2-3157H | Recombinant Human TSEN2 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
|
|
| TSEN2-5970R | Recombinant Rat TSEN2 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
|
|
| TSEN2-5970R-B | Recombinant Rat TSEN2 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
|
||
| TSEN2-9668M | Recombinant Mouse TSEN2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
|
|
| TSEN2-9668M-B | Recombinant Mouse TSEN2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
|
Involved Pathway
TSEN2 involved in several pathways and played different roles in them. We selected most pathways TSEN2 participated on our site, such as Gene Expression,tRNA processing,tRNA processing in the nucleus, which may be useful for your reference. Also, other proteins which involved in the same pathway with TSEN2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Gene Expression | RRN3,SURF1,ZNF529,ZNF133,D1BWG0212E,IGF2BP1,HNRNPD,SUPT4H1,SNRNP48,ZNF556 |
| tRNA processing in the nucleus | TSEN15,RPP14,TSEN34,TSEN54,FAM98B,ZBTB8OS,ELAC2,POP7,RPP30,C14orf166 |
| tRNA processing | POP4,PUS7,LBH,TYW5,ALKBH8,KIAA1456,LCMT2,ADAT3,TRMT112,POP1 |
Protein Function
TSEN2 has several biochemical functions, for example, lyase activity,nucleic acid binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TSEN2 itself. We selected most functions TSEN2 had, and list some proteins which have the same functions with TSEN2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | ICA1,PIK3IP1,OTUB1,HNRNPK,HNRNPA2B1,TESC,EFCAB11,TAGLN,CDC26,CRIPT |
| lyase activity | PTGES2,ALDOCA,ALDOAA,CAR1,GUCY2F,ADCY1B,ADCY2B,Car14,MVDA,TYW1B |
| nucleic acid binding | GTF2H2,TREX2,FTSJD2,ZFP191,HNRNPL2,SCRT1B,SRSF2B,ZFP422,ARL14EP,ZNF200 |
| tRNA-intron endonuclease activity | TSEN34,TSEN15 |
Interacting Protein
TSEN2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TSEN2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TSEN2.
TSEN54;Clp1
Resources
Related Services
Related Products
References
- Hu, QD; Lu, H; et al. A human homolog of the yeast gene encoding tRNA 2 '-phosphotransferase: cloning, characterization and complementation analysis. CELLULAR AND MOLECULAR LIFE SCIENCES 60:1725-1732(2003).
