TRPC6
-
Official Full Name
transient receptor potential cation channel, subfamily C, member 6 -
Overview
The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2). [provided by RefSeq, Mar 2009] -
Synonyms
TRPC6;transient receptor potential cation channel, subfamily C, member 6;TRP6;FSGS2;short transient receptor potential channel 6;TRP-6;transient receptor protein 6;focal segmental glomerulosclerosis 2
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| TRPC6-347H | Recombinant Human TRPC6 Protein, His-tagged | E.coli | Human | His | Met1~Leu192 | |
| TRPC6-741HCL | Recombinant Human TRPC6 293 Cell Lysate | HEK293 | Human | Non |
|
|
| RFL28781BF | Recombinant Full Length Bovine Short Transient Receptor Potential Channel 6(Trpc6) Protein, His-Tagged | E.coli | Bovine | His | Full L. Full Length (1-89) |
|
| TRPC6-1162HFL | Recombinant Human TRPC6 protein, His&Flag-tagged | HEK293 | Human | His&Flag | 1-931 aa |
|
| TRPC6-754H | Recombinant Human TRPC6 protein, hFc-tagged | HEK293 | Human | Fc | 543-592aa |
|
Involved Pathway
TRPC6 involved in several pathways and played different roles in them. We selected most pathways TRPC6 participated on our site, such as cGMP-PKG signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRPC6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| cGMP-PKG signaling pathway | GNAQ,PRKG2,PIK3R1,NOS3,PPP3CA,MEF2D,INSR,MEF2C,ATP1A2,Adcy4 |
Protein Function
TRPC6 has several biochemical functions, for example, inositol 1,4,5 trisphosphate binding,protein binding,store-operated calcium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TRPC6 itself. We selected most functions TRPC6 had, and list some proteins which have the same functions with TRPC6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| store-operated calcium channel activity | TRPC2B,TRPC3,STIM2,ORAI3,TRPC1,TRPC7A,TRPC6A,ORAI1B,ORAI2,TRPC2 |
| protein binding | RPL11,C7orf42,GBAS,AGAP2,INPP4B,ZC3HC1,XPO1,C1D,PEAK1,Artn |
| inositol 1,4,5 trisphosphate binding | ITPR3,PLCL1,TRPC3,TRPC2,TRPC1,TRPC2B,CYTH2,AKR1C1,TRPC5,TRPC7A |
Interacting Protein
TRPC6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRPC6 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRPC6.
MX1;ITPR3
Resources
Related Services
Related Products
References
- Zhang, JC; Mao, XB; et al. IL-17A CONTRIBUTES TO BRAIN ISCHEMIA REPERFUSION INJURY THROUGH CALPAIN-TRPC6 PATHWAY IN MICE. NEUROSCIENCE 274:419-428(2014).
- Abkhezr, M; Dryer, SE; et al. Angiotensin II and Canonical Transient Receptor Potential-6 Activation Stimulate Release of a Signal Transducer and Activator of Transcription 3-Activating Factor from Mouse Podocytes. MOLECULAR PHARMACOLOGY 86:150-158(2014).
