This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternate transcriptional splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
NTRK2 involved in several pathways and played different roles in them. We selected most pathways NTRK2 participated on our site, such as MAPK signaling pathway, Neurotrophin signaling pathway, Alcoholism, which may be useful for your reference. Also, other proteins which involved in the same pathway with NTRK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
NTRK2 has several biochemical functions, for example, ATP binding, brain-derived neurotrophic factor binding, brain-derived neurotrophic factor-activated receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NTRK2 itself. We selected most functions NTRK2 had, and list some proteins which have the same functions with NTRK2. You can find most of the proteins on our site.
NTRK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NTRK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NTRK2.
Pajtler, KW; Mahlow, E; et al. Neuroblastoma in dialog with its stroma: NTRK1 is a regulator of cellular cross-talk with Schwann cells. ONCOTARGET 5:11180-11192(2014).
Wessels, JM; Wu, L; et al. The Brain-Uterus Connection: Brain Derived Neurotrophic Factor (BDNF) and Its Receptor (Ntrk2) Are Conserved in the Mammalian Uterus. PLOS ONE 9:-(2014).
