Trim63
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Official Full Name
tripartite motif containing 63, E3 ubiquitin protein ligase -
Overview
This gene encodes a member of the RING zinc finger protein family found in striated muscle and iris. The product of this gene is an E3 ubiquitin ligase that localizes to the Z-line and M-line lattices of myofibrils. This protein plays an important role in the atrophy of skeletal and cardiac muscle and is required for the degradation of myosin heavy chain proteins, myosin light chain, myosin binding protein, and for muscle-type creatine kinase. [provided by RefSeq, Feb 2012] -
Synonyms
TRIM63;tripartite motif containing 63, E3 ubiquitin protein ligase;IRF;SMRZ;MURF1;MURF2;RNF28;E3 ubiquitin-protein ligase TRIM63;ring finger protein 28;iris ring finger protein;muscle specific ring finger protein 2;muscle-specific RING finger protein 1;tripartite motif-containing protein 63;striated muscle RING zinc finger protein
Recombinant Proteins
- Human
- Rat
- Zebrafish
- Rhesus macaque
- Mouse
- E.coli
- Wheat Germ
- Mammalian Cells
- HEK293
- His&SUMO
- Non
- GST
- His
- SUMO
- His&Myc
- Avi&Fc&His
Involved Pathway
Trim63 involved in several pathways and played different roles in them. We selected most pathways Trim63 participated on our site, such as Adaptive Immune System,Antigen processing: Ubiquitination &,Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trim63 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adaptive Immune System | IGKC,AP1G1,MKRN1,KLC3,DYNC1H1,CTSD,UBE2U,PTBP3,CTSLL,EGFR |
| Immune System | FAM49BA,GRAP2A,IL1RN,UNC93B1,TIRAP,TCIRG1,DEFB4B,RNF220,TREX1,POLR3H |
| TWEAK Signaling Pathway | TNFSF12-TNFSF13 |
| Proteasome degradation | UBE2L6,LRR1,TPP2,ASB10,UBE2V2,ASB6,TRIM41,RNF4,ASB2,LRSAM1 |
| Antigen processing: Ubiquitination & | PJA1,RNF14,LRRC41,FBXO3,DZIP3,UBR2,UBE2V2,STUB1,RNF4,RBCK1 |
| presentation | CYBB,TRIM69,LTN1,BLMH,FBXO44,ASB3,TPP2,ERAP1,ASB4,TRAF7 |
| Class I MHC mediated antigen processing & | CD207,KLHL20,TRIM11,FBXO3,TRIM69,FBXO44,SPSB1,UFL1,ARIH2,TRIM9 |
Protein Function
Trim63 has several biochemical functions, for example, ligase activity,protein binding,signal transducer activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Trim63 itself. We selected most functions Trim63 had, and list some proteins which have the same functions with Trim63. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| titin binding | CALM1,CAPN3,ACTN2,CALM,MYBPC1,OBSCN,CALM3,ANKRD1,ANKRD1B,ANKRD23 |
| signal transducer activity | PPFIA1,GNG13,VAPA,GPR161,DRD4B,MIER1,CBL,AGTR1B,FKBP1A,PLCD4 |
| ligase activity | ACSM2,HECTD2,RNF34,UNKL,HACE1,UBE2NB,UBE2I,RNF114,RNF4,UFL1 |
| protein binding | FN1,MYCBP,TBC1D5,NR3C1,ANO2,PPP3R2,NAMPT,PRKACB,CALCOCO1,HAGH |
| zinc ion binding | ADH1B,RECQL4,ARIH1,ADAM30,DTX4,RORB,HDAC4,MUL1A,ZCCHC17,PHRF1 |
| ubiquitin protein ligase activity | UBE2J1,UBR2,HECTD2,UBE2R2,RNF4,HERC2,FBXO6,HERC3,HECW1B,CDC42 |
Interacting Protein
Trim63 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trim63 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trim63.
TTN;EEF1G;CCAR1;MRPL41;GFM1;MYOZ1;NDUFA1;TCAP;NEBL;SNAPIN;ATP5B;TNNT1
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