TRIM28
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Official Full Name
tripartite motif containing 28 -
Overview
The protein encoded by this gene mediates transcriptional control by interaction with the Kruppel-associated box repression domain found in many transcription factors. The protein localizes to the nucleus and is thought to associate with specific chromatin regions. The protein is a member of the tripartite motif family. This tripartite motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. -
Synonyms
TRIM28;tripartite motif containing 28;transcription intermediary factor 1-beta;KAP1;RNF96;TF1B;TIF1B;KAP-1;KRIP-1;TIF1-beta;RING finger protein 96;KRAB-associated protein 1;nuclear corepressor KAP-1;KRAB-interacting protein 1;E3 SUMO-protein
Recombinant Proteins
- Human
- Rat
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Flag&His
- Non
- DDK&Myc
- His&T7
- Flag
- Avi&Fc&His
Involved Pathway
TRIM28 involved in several pathways and played different roles in them. We selected most pathways TRIM28 participated on our site, such as C-MYB transcription factor network,Corticotropin-releasing hormone,E2F transcription factor network, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRIM28 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| E2F transcription factor network | E2F6,PRMT5,CES5A,YY1,DHFR,RBBP8,MYBL2,CBX5,RYBP,E2F4 |
| p53 pathway | TTC5,E4F1,PPP1R13L,RASSF1,NEDD8,CSE1L,HUWE1,KAT8,CSNK1G3,SMYD2 |
| C-MYB transcription factor network | COL1A2,CSF1R,ELANE,MYB,PPID,CLTA,CEBPA,ADORA2B,CBX4,CDK6 |
| Generic Transcription Pathway | RARAB,SESN3,ZNF556,ZNF180,MED8,ZNF71,ZNF454,MED31,ZNF561,ZNF597 |
| Gene Expression | ZNF496,SSRP1A,ADAR,CHD4A,SKILB,UHRF1,PRDM7,AEBP2,ZNF777,ZNF498 |
| Corticotropin-releasing hormone | CRHR1,CRH,CYP21A2,KRT14,CYP11A1,CRHR2,ECE1,CRHBP,JUND,IVL |
Protein Function
TRIM28 has several biochemical functions, for example, DNA binding,Krueppel-associated box domain binding,RNA polymerase II transcription coactivator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TRIM28 itself. We selected most functions TRIM28 had, and list some proteins which have the same functions with TRIM28. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin protein ligase binding | FAF1,RNF40,CKB,H2-AB1,FHIT,WASH,PRKACB,AURKA,RBX1,HSPA8 |
| contributes_to transcription factor activity, sequence-specific DNA binding | TAF10,MAFGA,TAF7,TAF6,NKX2-5,NFE2L2A,VDR,HNRNPAB,SMAD2,SOX1B |
| contributes_to sequence-specific DNA binding | HIF1A,SMAD4,EPAS1,PPARG,NEUROD1,TCF3,FIGLA,HDAC4,ARNT,HNRNPAB |
| transcription corepressor activity | ATN1,SKOR1B,MXD1,E2F6,THRB,MXD4,SKOR1A,ZHX3,CCND1,ATF5 |
| protein kinase activity | PDK3,TGFBR1B,PRKCDA,TBK1,NPR1A,TLK1B,RPS6KA3,RLN1,RPS6KAL,SGK2A |
| RNA polymerase II transcription coactivator activity | POU1F1,NEUROD1,SOX12,HYAL2,POU3F2,SOX11,CITED1,TBX20,MKL1,WBP2 |
| chromo shadow domain binding | NIPBL,ATRX,SP100,LBR,CHAF1A |
| ubiquitin-protein transferase activity | CMTM2A,TRIM21,HUWE1,RNF31,PDZRN3B,RNF139,SMURF1,TRIM5,FEM1A,BIRC2 |
| ligase activity | TRAF7,TRIM63,RNF114,TRAF3,UHRF2,SYVN1,UBE3A,HERC3,PJA1,HACE1 |
Interacting Protein
TRIM28 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRIM28 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRIM28.
MAGEC2;CBX5
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References
- Addison, JB; Koontz, C; et al. KAP1 Promotes Proliferation and Metastatic Progression of Breast Cancer Cells. CANCER RESEARCH 75:344-355(2015).
- Lee, M; Dworkin, AM; et al. Metastasis-Associated Protein Ribosomal RNA Processing 1 Homolog B (RRP1B) Modulates Metastasis through Regulation of Histone Methylation. MOLECULAR CANCER RESEARCH 12:1818-1828(2014).
