TRAF1
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Official Full Name
TNF receptor-associated factor 1 -
Overview
TRAFs (TNF receptor-associated factors) are a family of multifunctional adaptor proteins that bind to surface receptors and recruit additional proteins to form multiprotein signaling complexes capable of promoting cellular responses (1-3). Members of the -
Synonyms
TRAF1;TNF receptor-associated factor 1;EBI6;Epstein-Bar virus-induced protein 6;MGC:10353
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Zebrafish
- E.coli
- Mammalian Cells
- HEK293
- His
- GST&His
- Non
- Avi&Fc&His
- DDK&Myc
Involved Pathway
TRAF1 involved in several pathways and played different roles in them. We selected most pathways TRAF1 participated on our site, such as NF-kappa B signaling pathway,TNF signaling pathway,Herpes simplex infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRAF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| TNF signaling pathway | IL1B,CXCL3,IKBKG,MAP2K1,CASP8,VCAM1,MMP3,MAPK11,ATF4,ICAM1 |
| Viral carcinogenesis | GTF2H2C,PIK3CD,CCND1,NFKB1,HIST1H4E,NRAS,PSMC1,DLG1,GTF2B,RBPJL |
| Small cell lung cancer | ITGA3,LAMA4,AKT1,LAMB1,BIRC8,PIK3R2,PIK3CB,BIRC2,LAMA2,TRP53 |
| NF-kappa B signaling pathway | PLCG1,ERC1,LCK,BCL10,ATM,LYN,RELA,TNFSF13B,TICAM2,TNFAIP3 |
| Transcriptional misregulation in cancer | HIST1H3I,FEV,SLC45A3,IGF1,ITGB7,MEN1,GZMB,SPI1,ETV4,BMP2K |
| Herpes simplex infection | SRSF7B,SRSF1A,PPP1CA,STAT1B,PKZ,IL1B,IRF3,IFNG,SRSF3,THOC4 |
| Epstein-Barr virus infection | POLR1D,NCOR2,NEDD4,POLR2B,HSPA1A,PTMA,TRAF2,HSPB1,TYK2,TRAF6 |
| Pathways in cancer | FGF18,RUNX1T1,HSP90AB1,SPI1,HDAC2,EGLN1,Shh,WNT1,FGFR1,RAD51 |
Protein Function
TRAF1 has several biochemical functions, for example, protein binding,thioesterase binding,tumor necrosis factor receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TRAF1 itself. We selected most functions TRAF1 had, and list some proteins which have the same functions with TRAF1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | PRAM1,UBE2G2,CSRNP2,CEP55,PSMA1,HCFC1,MYOZ2,RNF10,PSMA6,OTUD7B |
| tumor necrosis factor receptor binding | TNFSF14,LTA,TRIM37,TNFSF10L3,TNFSF13,TRAF2,TNF,TNFSF10,TNFSF10L4,TRADD |
| ubiquitin protein ligase binding | GSK3B,UBE2L3,HSPA1L,HSPA1A,AKTIP,HM13,UBOX5,CASP10,UBE2Z,CASP8 |
| zinc ion binding | CCS,MEP1B,RNF115,SHARPIN,PMPCB,SIAH1A,ADAMTSL5,TGFB1I1,RNF212,TK1 |
| thioesterase binding | TRAF3,TRAF6,TRAF4,CALM,CALM3,RAC1,CDC42,CALM1,HAUS7,TRAF2 |
Interacting Protein
TRAF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRAF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRAF1.
TRAF6;RIPK1;TRAF2
Resources
Research Area
Apoptosis Adaptor ProteinsAdaptor Proteins
Inflammatory Mediators
Ubiquitin-related Molecules in the Akt Pathway
E3 Ubiquitin Ligases
Related Services
Related Products
References
- Lassen, UN; Meulendijks, D; et al. APhase I Monotherapy Study of RG7212, a First-in-Class Monoclonal Antibody Targeting TWEAK Signaling in Patients with Advanced Cancers. CLINICAL CANCER RESEARCH 21:258-266(2015).
- Settin, A; Salama, A; et al. Signal transducer and activator of transcription 4 (STAT4) G > T gene polymorphism in Egyptian cases with rheumatoid arthritis. HUMAN IMMUNOLOGY 75:863-866(2014).
