TPD52L1
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Official Full Name
tumor protein D52-like 1 -
Overview
This gene encodes a member of the tumor protein D52 (TPD52) family. The encoded protein contains a coiled-coil domain and may form homo- or hetero-dimer with TPD52 family members. The protein is reported to be involved in cell proliferation and calcium signaling. It also interacts with the mitogen-activated protein kinase kinase kinase 5 (MAP3K5/ASK1) and positively regulates MAP3K5-induced apoptosis. Multiple alternatively spliced transcript variants have been observed, but the full-length nature of some variants has not yet been determined. -
Synonyms
TPD52L1;tumor protein D52-like 1;tumor protein D53;D53;hD53;MGC8556
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Rhesus macaque
- Chicken
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- DDK
- Myc
- Avi
- Fc
Involved Pathway
TPD52L1 involved in several pathways and played different roles in them. We selected most pathways TPD52L1 participated on our site, such as Clathrin derived vesicle budding,Golgi Associated Vesicle Biogenesis,Membrane Trafficking, which may be useful for your reference. Also, other proteins which involved in the same pathway with TPD52L1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| trans-Golgi Network Vesicle Budding | SNX9A,CLINT1,TCEAL4,FTH1A,NECAP1,HIP1R,AP4B1,TFR1B,HIP1RB,SH3D19 |
| Membrane Trafficking | SNX9,DAB2,TFG,NAPB,TRAPPC3,BLOC1S4,TCEAL4,GORASP1,TPD52,COPZ1 |
| Clathrin derived vesicle budding | AP1G1,PICALMA,BLOC1S3,CLVS1,HIP1RB,TBC1D8B,PICALM,AP1S1,NAPAB,TPD52 |
| Vesicle-mediated transport | FTH1A,TERFA,STXBP3,CLVS2,TRAPPC3,TRAPPC9,GJB7,BLOC1S6,HIP1R,PPP6R3 |
| Golgi Associated Vesicle Biogenesis | PICALMB,CPD,SNX9A,TBC1D8B,SNX9,TPD52,CLINT1,FTH1B,PLDN,TGOLN2 |
Protein Function
TPD52L1 has several biochemical functions, for example, identical protein binding,protein binding,protein heterodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TPD52L1 itself. We selected most functions TPD52L1 had, and list some proteins which have the same functions with TPD52L1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| identical protein binding | UBQLN1,IFIT3,C,PTK6,CCL4,PLDN,ATG16L1,ROBO2,SHANK3,PNMA5 |
| protein homodimerization activity | DRD2,TCF3A,CASQ2,S100A1,ZBTB16,CHMP4C,PDGFA,PPP2R4,CTBP2A,BST2 |
| protein binding | CMTM3,SVIL,APC,RLN3,CDC6,USP14,PTPRD,CLIC5,TPD52L2,PHIP |
| protein heterodimerization activity | ANO2,H2AFY,UGT1A6B,NR4A1,H3F3B.1,HNF1B,JAM2A,SDCBP2,DDIT3,HIST1H4H |
Interacting Protein
TPD52L1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TPD52L1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TPD52L1.
YWHAB;YWHAZ;TPD52L2;TPD52L2;EIF3J;SFN;ABL2;TPD52;HDAC1
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References
- Yamaga, R; Ikeda, K; et al. RNA Sequencing of MCF-7 Breast Cancer Cells Identifies Novel Estrogen-Responsive Genes with Functional Estrogen Receptor-Binding Sites in the Vicinity of Their Transcription Start Sites. HORMONES & CANCER 4:222-232(2013).
- Fanayan, S; Shehata, M; et al. Mucin 1 (MUC1) is a novel partner for MAL2 in breast carcinoma cells. BMC CELL BIOLOGY 10:-(2009).
