TIA1
-
Official Full Name
TIA1 cytotoxic granule-associated RNA binding protein -
Overview
The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms of this gene product has been described in the literature. [provided by RefSeq, Jul 2008] -
Synonyms
TIA1;TIA1 cytotoxic granule-associated RNA binding protein;WDM;TIA-1;nucleolysin TIA-1 isoform p40;p40-TIA-1 (containing p15-TIA-1);T-cell-restricted intracellular antigen-1
Recombinant Proteins
- Human
- Cynomolgus
- Zebrafish
- Chicken
- Rhesus macaque
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- Mammalian cells
- HEK293T
- GST
- His
- Non
- Myc&DDK
- Flag
- His&Fc&Avi
Involved Pathway
TIA1 involved in several pathways and played different roles in them. We selected most pathways TIA1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with TIA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
TIA1 has several biochemical functions, for example, AU-rich element binding,nucleotide binding,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TIA1 itself. We selected most functions TIA1 had, and list some proteins which have the same functions with TIA1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| nucleotide binding | MTHFSD,CELF6,UBE2KA,CDC42L2,EEFSEC,RBMY1A1,MYO15,ADCY1A,MSI2,SEPT4A |
| protein binding | KLHL2,RPGR,EVC2,SHD,SYAP1,MRE11A,TRIM21,PRPF3,AMY1A,SPC25 |
| AU-rich element binding | APOBEC1,DND1,ZFP36L3,CPSF5,ELAVL3,ELAVL4,HNRNPA0,NUDT21,EXOSC9,ELAVL1 |
| poly(A) RNA binding | CCDC86,LTA4H,CNOT1,DDX49,RPL12,DHX35,PABPC4,MRPS23,ANKRD17,SNRPD1 |
| poly(A) binding | SYNCRIP,PABPN1,PABPC1,ZC3H14,KHDRBS1,EIF4A3,PABPC4,DDX3X,PAIP2B,HNRNPDL |
Interacting Protein
TIA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TIA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TIA1.
SF1;q7ard2_yerpe;syd;mnmG;trpA;hslU;ssrna_ug
Resources
Related Services
Related Products
References
- Kim, J; Park, CJ; et al. A Case of CD4(+)T-Cell Large Granular Lymphocytic Leukemia. ANNALS OF LABORATORY MEDICINE 33:196-199(2013).
- Matsushita, Y; Takeshita, M; et al. Paediatric T-cell lymphoma of the appendix: a case report. DIAGNOSTIC PATHOLOGY 8:-(2013).
