THRB
-
Official Full Name
THRB thyroid hormone receptor, beta -
Overview
The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors;for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in;mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions;of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a;syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly;elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same;protein have been observed for this gene. -
Synonyms
THRB;thyroid hormone receptor, beta;thyroid hormone receptor beta;avian erythroblastic leukemia viral (v erb a) oncogene homolog 2;ERBA BETA;generalized resistance to thyroid hormone;GRTH;NR1A2;oncogene ERBA2;THR1;THRB1;THRB2;thyroid hormone receptor beta 1;nuclear receptor subfamily 1 group A member 2;thyroid hormone nuclear receptor beta variant 1;thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian);PRTH;ERBA2;C-ERBA-2;C-ERBA-BETA;MGC126109;MGC126110
Recombinant Proteins
- Human
- Bacillus subtilis
- Mouse
- Chicken
- Zebrafish
- E.coli
- Sf9 Insect Cell
- E. coli or Yeast
- Mammalian Cell
- HEK293
- Human Cells
- HEK293T
- Non
- GST
- His
- His&T7
- Flag
- Myc&DDK
- His&SUMO
- His&Fc&Avi
Involved Pathway
THRB involved in several pathways and played different roles in them. We selected most pathways THRB participated on our site, such as Neuroactive ligand-receptor interaction,Thyroid hormone signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with THRB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Neuroactive ligand-receptor interaction | GRM1,TAAR1B,P2RY2,PTAFR,BDKRB2,CSH2,NMUR2,MC5RA,LEPR,TACR2 |
| Thyroid hormone signaling pathway | BAD,HDAC1,MED12L,DIO3,PLCE1,PLN,PIK3R2,KAT2B,ITGB3,AKT2 |
Protein Function
THRB has several biochemical functions, for example, DNA binding,chromatin DNA binding,enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by THRB itself. We selected most functions THRB had, and list some proteins which have the same functions with THRB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| enzyme binding | GSTM7,PEBP1,ATF7,GSTM1,CDK19,CLSTN2,KPNB1,PRKCH,MTA1,P4HB |
| DNA binding | ZNF207,ZFP654,ZBTB41,PPARAB,MCM2,HYPM,PALB2,ZNF3,POLE2,FOXM1 |
| transcription corepressor activity | MXD1,ID4,PEX14,DAXX,NCOR2,ZHX1,TSG101,SKI,TDP2,HDAC5 |
| zinc ion binding | APOBEC4,TRAF4B,RNF125,DNMT1,RNF130,DDX41,USP51,MTA2,NR5A1,SYTL4 |
| sequence-specific DNA binding | PAX3,POU3F2A,HOXA13B,UNCX,SOX13,MEOX2B,LHX1B,USF1,NKX2,HEY2 |
| chromatin DNA binding | RARA,AASS,ZIC2,H2AFZ,GRHL2,WBP2,XBP1,HIST1H1E,INSM1A,RXRA |
| thyroid hormone receptor activity | NR1D4A,THRAA,THRA,NR2F6,NR1H4,BRD8,NR1D2A,NR1D4B,NR1I3,NR4A3 |
| steroid hormone receptor activity | NR5A1B,NR1D2,NR5A1,RORA,RXRBA,NR4A1,RARGB,PAQR8,ESRRG,PPARD |
| thyroid hormone binding | CRYM,CTSH,THRA,ALDH1A3 |
Interacting Protein
THRB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with THRB here. Most of them are supplied by our site. Hope this information will be useful for your research of THRB.
Rxra;PRMT2;CNOT1;NCOA6;MED25;ADAT3;Ncoa6
Resources
Related Services
Related Products
References
