THRA
-
Official Full Name
thyroid hormone receptor, alpha -
Overview
The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported. -
Synonyms
THRA;thyroid hormone receptor, alpha;thyroid hormone receptor alpha;AR7;EAR 7.1/EAR 7.2;ERBA;NR1A1;THRA3;c erbA 1;C erbA alpha;EAR7;ERBA1;Thyroid hormone receptor alpha 2;TR alpha 2;EAR-7;c-erbA-alpha;ERBA-related 7;OTTHUMP00000164469;OTTHUMP00000164470;V-erbA-related protein 7;triiodothyronine receptor;nuclear receptor subfamily 1 group A member 1;thyroid normone nuclear receptor alpha variant 1;thyroi;THRA1;THRA2;ERB-T-1;c-ERBA-1
Recombinant Proteins
- Human
- Mouse
- Rat
- Chicken
- Sf9 Cells
- E.coli
- Sf21 Cells
- Mammalian Cells
- HEK293
- His
- GST
- Non
- Flag
- Myc&DDK
- His&B2M
- His&Fc&Avi
Involved Pathway
THRA involved in several pathways and played different roles in them. We selected most pathways THRA participated on our site, such as Neuroactive ligand-receptor interaction,Thyroid hormone signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with THRA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Neuroactive ligand-receptor interaction | S1PR3,PTGER2A,S1PR4,PTH1R,GRM7,TAAR14H,F2RL3,LPAR6A,NPY8AR,TRY |
| Thyroid hormone signaling pathway | RHEB,ATP1A2,ESR1,MED17,KAT2A,NCOA1,MAP2K2,PRKACB,FOXO1,PRKCB |
Protein Function
THRA has several biochemical functions, for example, TBP-class protein binding,chromatin DNA binding,intronic transcription regulatory region DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by THRA itself. We selected most functions THRA had, and list some proteins which have the same functions with THRA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| zinc ion binding | NHLRC1,TRIM65,LMX1BB,WBP7,KDM5A,TRIM5,LHX3,PHF8,MTA2,JHDM1D |
| thyroid hormone binding | ALDH1A3,CTSH,CRYM,THRB |
| protein complex binding | CALCA,NSF,EP300,IGBP1,PEX26,KIF11,INS2,PRMT5,CEBPA,BAG3 |
| transcription factor binding | TRIB2,DRG1,PPP1R13BB,TAF7,PAX6,HMGA1-RS1,PPID,PRICKLE1,IRF4,BCL3 |
| transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | SRY,FOXF1,SFPI1,RFX1,AHR,GATA4,ATF1,PKNOX1,NR5A2,FOXC2 |
| transcription factor activity, sequence-specific DNA binding | NEUROD2,ZFP28,FOXS1,L3MBTL1,ZNF157,KLF17,MAP3K7,UHRF1,ETS1,NFIL3-2 |
| protein heterodimerization activity | ADORA2A,HIST1H2A9,DVL3,HER1,BDKRB2,BTBD11,Fzd4,GRIN1,ENO2,CASP8 |
| TBP-class protein binding | TAF1,CAND2,PSMC3,EFCAB11,TAF1B,BRF1A,BRF1,PSMC1,GTF2A1,TAF1L |
| sequence-specific DNA binding | NKX2-3,NKX6.3,ZNF238,TBX5,GBX1,HOXC13,FOXO3,MEOX2B,OTPA,FOXN3 |
Interacting Protein
THRA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with THRA here. Most of them are supplied by our site. Hope this information will be useful for your research of THRA.
MED1;L3MBTL3;AMOTL2;Ncoa6;PKM;UBA1;UBE2N;AKAP13;UBE2V1;TXNRD1;CLIC1
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