THBS2
-
Official Full Name
thrombospondin 2 -
Overview
The protein encoded by this gene belongs to the thrombospondin family. It is a disulfide-linked homotrimeric glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein has been shown to function as a potent inhibitor of tumor growth and angiogenesis. Studies of the mouse counterpart suggest that this protein may modulate the cell surface properties of mesenchymal cells and be involved in cell adhesion and migration. [provided by RefSeq, Jul 2008] -
Synonyms
THBS2;thrombospondin 2;TSP2;thrombospondin-2
Recombinant Proteins
- Human
- Chicken
- Mouse
- Rat
- E.coli
- Mammalian cells
- Mammalian Cell
- HEK293
- Yeast
- His
- His&T7
- His&GST
- Non
- His&Fc&Avi
Involved Pathway
THBS2 involved in several pathways and played different roles in them. We selected most pathways THBS2 participated on our site, such as Phagosome,PIK-Akt signaling pathway,Focal adhesion, which may be useful for your reference. Also, other proteins which involved in the same pathway with THBS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Focal adhesion | MET,COL2A1,MAP2K1,CAV2,MYL9A,PAK3,ITGB3B,Pdgfa&Pdgfb,PARVB,MYLK2 |
| Phagosome | ATP6V1C1,TUBA8L2,TUBB2,NOS1,BLB2,ITGA2,TUBA3B,ATP6V0CB,TUBA8,VAMP3 |
| Malaria | TGFB1,CD36,IFNG,HGF,HBA1,HBA-A2,TGFB3,CSF3,IL1B,ITGB2 |
| PIK-Akt signaling pathway | FGF4,IL3RA,LPAR6,GH1,GNG4,IFNA21,GNB4,VEGFC,FGF9,PRKAA1 |
| ECM-receptor interaction | ITGA10,CHAD,FN1A,COL1A1,TNN,SDC1,SPP1,COL11A1A,COL2A1B,COL4A6 |
Protein Function
THBS2 has several biochemical functions, for example, calcium ion binding,heparin binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by THBS2 itself. We selected most functions THBS2 had, and list some proteins which have the same functions with THBS2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium ion binding | SNCA,NUCB2B,GUCA1D,THBS3,TNNC1,NUCB2A,MASP1,PLA2G4A,NELL2A,ANXA1B |
| protein binding | RAB8B,KCNA1,PKN1,NDFIP2,MCM8,BLVRA,UBE2F,DYDC1,TSC2,CDKN2B |
| heparin binding | PTPRFB,APLP2,GREM2,C6orf25,CCL2,SFRP1,CXCL10,APPA,ELANE,RPL29 |
Interacting Protein
THBS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with THBS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of THBS2.
Cacna2d1
THBS2 Related Signal Pathway
Resources
Research Area
Angiogenesis InhibitorNotch Family
Synaptic Proteins
Extracellular Matrix Molecules
Angiogenesis Inhibitor in Cancer
Related Services
Related Products
References
- Lin, D; Alborn, WE; et al. Comparison of Protein Immunoprecipitation-Multiple Reaction Monitoring with ELISA for Assay of Biomarker Candidates in Plasma. JOURNAL OF PROTEOME RESEARCH 12:5996-6003(2013).
- Czekierdowski, A; Czekierdowska, S; et al. MICROVESSEL DENSITY AND CPG ISLAND METHYLATION OF THBS2 GENE IN MALIGNANT OVARIAN TUMORS. JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY 59:53-65(2008).
