TFB1M
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Official Full Name
transcription factor B1, mitochondrial -
Overview
The protein encoded by this gene is a dimethyltransferase that methylates the conserved stem loop of mitochondrial 12S rRNA. The encoded protein also is part of the basal mitochondrial transcription complex and is necessary for mitochondrial gene expression. The methylation and transcriptional activities of this protein are independent of one another. Variations in this gene may influence the severity of aminoglycoside-induced deafness (AID). -
Synonyms
TFB1M;transcription factor B1, mitochondrial;dimethyladenosine transferase 1, mitochondrial;CGI 75;dimethyladenosine transferase 1;mitochondrial;mtTFB;hmtTFB;hmtTFB1;hTFB1M;Mitochondrial 12S rRNA dimethylase 1;Mitochondrial transcription factor B1;mtTFB1;h-mtTFB;h-mtTFB1;Mitochondrial dimethyladenosine transferase 1;TFB1M_HUMAN;Transcription factor B1 mitochondrial;homolog of yeast mitochondrial transcription factor B;S-adenosylmethionine-6-N, N-adenosyl(rRNA) dimethyltransferase 1;CGI75;CGI-75
Recombinant Proteins
- Human
- Cynomolgus
- Mouse
- Zebrafish
- Rhesus macaque
- Rat
- E.coli
- Mammalian Cells
- Human
- HEK293
- GST
- His
- Non
- His&Fc&Avi
Involved Pathway
TFB1M involved in several pathways and played different roles in them. We selected most pathways TFB1M participated on our site, such as Energy Metabolism,Mitochondrial Gene Expression,Mitochondrial biogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with TFB1M were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Transcriptional activation of mitochondrial biogenesis | POLRMT,POLG2,MTERF,GABPB1,PPRC1,GABPA,C10orf2 |
| Organelle biogenesis and maintenance | NPHP3,MRPL49,MRPL44,NPHP1,MRPS33,OST4,EXOC1,ATAT1,TCTN3,HSPB11 |
| Energy Metabolism | ESRRA,MYBBP1A,TFB2M,GABPA,UCP3,PPARGC1B,MEF2B,UCP2 |
| Mitochondrial Gene Expression | PPARGC1B,ESRRA,TFB2M,PPRC1,POLRMT,MTERFD1 |
| Mitochondrial biogenesis | PPARGC1B,TFB2M,POLG2,MTERF,GABPB1,GABPA,C10orf2,POLRMT,PPRC1,ESRRA |
Protein Function
TFB1M has several biochemical functions, for example, DNA binding,poly(A) RNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TFB1M itself. We selected most functions TFB1M had, and list some proteins which have the same functions with TFB1M. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| rRNA (adenine-N6,N6-)-dimethyltransferase activity | TRMT10C,TRMT10B,METTL21A,METTL7B,PRMT8B,PRDM12,METTL23,NDUFAF5,RRNAD1,RNMTL1A |
| DNA binding | KCNH7,RYBPA,ORC4,STAT1B,MYO18A,FOXP1A,ZFP143,RCAN1,THOC1,HMGA1B |
| protein binding | SYNJ2BP,ALDH7A1,ATE1,HEY1,EIF4H,ASF1A,DYNC1H1,SMAD9,GMPPA,POSTN |
| poly(A) RNA binding | CALR,NVL,PSIP1,EIF3E,WDR46,BCLAF1,CLTC,HSD17B10,STIP1,OTUD4 |
Interacting Protein
TFB1M has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TFB1M here. Most of them are supplied by our site. Hope this information will be useful for your research of TFB1M.
TFAM;s-adenosyl-l-methionine-1;POLRMT;Srp72;AP4M1;RPL10;YWHAH;ICT1;Rpl35;BAIAP2
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References
- Nabokina, SM; Valle, JE; et al. Characterization of the human mitochondrial thiamine pyrophosphate transporter SLC25A19 minimal promoter: A role for NF-Y in regulating, basal transcription. GENE 528:248-255(2013).
