TCF3
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Official Full Name
transcription factor 3 -
Overview
This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1;19), with PBX1), childhood leukemia (t(19;19), with TFPT) and acute leukemia (t(12;19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Sep 2011] -
Synonyms
TCF3;transcription factor 3;E2A;E47;ITF1;VDIR;TCF-3;bHLHb21;transcription factor E2-alpha;kappa-E2-binding factor;VDR interacting repressor;transcription factor ITF-1;helix-loop-helix protein HE47;transcription factor 3 variant 3;immunoglobulin transcription factor 1;vitamin D receptor-interacting repressor;class B basic helix-loop-helix protein 21;negative vitamin D response element-binding protein;transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47);Pan2;Tcfe2a
Recombinant Proteins
- Human
- Rat
- Chicken
- Mouse
- E.coli
- Wheat Germ
- Mammalian Cells
- HEK293
- GST
- Non
- His
- Flag
- Avi
- Fc
- DDK
- Myc
Involved Pathway
TCF3 involved in several pathways and played different roles in them. We selected most pathways TCF3 participated on our site, such as Signaling pathways regulating pluripotency of stem cells,HTLV-I infection,Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with TCF3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Transcriptional misregulation in cancer | SSX2,SPINT1,FOXO1,MLLT1,HIST2H3C2,SMAD1,PLAU,RUNX2,MAF,ETV5 |
| HTLV-I infection | DLG1,PRKACG,NFATC4,FZD10,DVL1,ANAPC7,ATF1,HLA-DOB,MSX2,ANAPC11 |
| Signaling pathways regulating pluripotency of stem cells | GSK3B,FZD2,HAND1,WNT10B,NRAS,PAX6,RAF1,PCGF5,IGF1R,BMI1 |
Protein Function
TCF3 has several biochemical functions, for example, DNA binding,contributes_to DNA binding,E-box binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TCF3 itself. We selected most functions TCF3 had, and list some proteins which have the same functions with TCF3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor binding | TNFRSF10A,CDKN2A,PIK3R1,TFDP1,APBB3,HES6,TFDP2,STAT3,NEUROD1,LEF1 |
| transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding | NFE2L3,TBX15,SKIL,NKX3-2,NKX6,PITX2,CUX2,CREBBP,MYPOP,HELT |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | PATZ1,FUBP3,CDX4,JDP2,SMAD1,PLAG1,DPF2,HNRNPK,RFX2,ZNF264 |
| repressing transcription factor binding | DDX20,MAGEA2,GMNN,MAGEA2B,RELA,CBX5,HHEX,HDAC5,HDAC4,PRDM5 |
| contributes_to E-box binding | MYF5,MYF6 |
| protein homodimerization activity | SLK,IKZF3,UGT1A6B,SHMT1,DLK2,DSCAML1,PTPRO,CHKA,BMPR1A,ROPN1B |
| contributes_to transcription regulatory region DNA binding | RXRA,HDAC4,NFYC,NR1H3,NFYB,HAND1,NFYA,ATF4,HDAC5,TCF12 |
| contributes_to sequence-specific DNA binding | PPARG,FIGLA,HIF1A,HNRNPAB,EPAS1,TRIM28,NEUROD1,HDAC4,SMAD4,ARNT |
| chromatin binding | TFAP2A,BRD2,MEIS1,HOXD10,LDB1,TSHZ3,NR5A1A,LHX2,PDX1,LDB2A |
Interacting Protein
TCF3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TCF3 here. Most of them are supplied by our site. Hope this information will be useful for your research of TCF3.
TAL1;ID3;TCAF1;ASCL1;dna-1;FOXH1;TCF12;Gata1;GATA2
Resources
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References
- Soldini, D; Georgis, A; et al. The combined expression of VPREB3 and ID3 represents a new helpful tool for the routine diagnosis of mature aggressive B-cell lymphomas. HEMATOLOGICAL ONCOLOGY 32:120-125(2014).
- Lindskog, C; Kuhlwilm, M; et al. Analysis of Candidate Genes for Lineage-Specific Expression Changes in Humans and Primates. JOURNAL OF PROTEOME RESEARCH 13:3596-3606(2014).
