TCEB1
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Official Full Name
transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C) -
Overview
This gene encodes the protein elongin C, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been identified. -
Synonyms
TCEB1;transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C);transcription elongation factor B (SIII), polypeptide 1 (15kD, elongin C);transcription elongation factor B polypeptide 1;SIII;Elo C;EloC;ELOC_HUMAN;Elongin 15 kDa subunit;Elongin C;Elongin-C;ElonginC;RNA polymerase II transcription factor SIII subunit C;SIII p15;TCEB 1;Transcription elongation factor B (SIII) polypeptide 1;transcription elongation factor B, polypeptide 1
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rhesus macaque
- Rat
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
Involved Pathway
TCEB1 involved in several pathways and played different roles in them. We selected most pathways TCEB1 participated on our site, such as HIF- signaling pathway,Ubiquitin mediated proteolysis,Pathways in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with TCEB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Renal cell carcinoma | MET,AHA-1,HGF,TGFA,AKT1,SLC2A1,RAPGEF1,HRAS,PAK1,PIK3CD |
| Pathways in cancer | SMAD2,PIK3CB,CSF1R,NKX3-1,Shh,PTGS2,PRKACB,NTRK1,TRAF1,LAMB4 |
| HIF- signaling pathway | AKT1,PFKL,PIK3CA,TEK,HKDC1,PIK3R5,HK3,RPS6,PIK3R1,TIMP1 |
| Ubiquitin mediated proteolysis | PIAS1,BIRC2,SMURF1,UBE2E2,UBE2F,UBE2G2,MGRN1A,FBXW11A,UBE2D2,CDC34 |
Protein Function
TCEB1 has several biochemical functions, for example, protein binding,contributes_to ubiquitin-protein transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TCEB1 itself. We selected most functions TCEB1 had, and list some proteins which have the same functions with TCEB1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to ubiquitin-protein transferase activity | KBTBD13,KEAP1A,UBE2S,KBTBD10,KLHDC7A,KLHL7,GAN,KLHL12,KLHL28,KLHL41 |
| protein binding | SLC26A3,ACYP2,AVPR1A,UQCC1,RANBP3,PRF1,EGLN3,ATP5O,MIS18BP1,NCS1 |
Interacting Protein
TCEB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TCEB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TCEB1.
TCEB2;VHL
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References
- Sarungbam, J; Hakimi, AA; et al. TCEB1-Mutated Renal Cell Carcinoma (RCC): An Entity With Clear Cytoplasm and Prominent Fibromuscular Stroma Is Distinct From Clear Cell Renal Cell Carcinoma (ccRCC). MODERN PATHOLOGY 28:257A-257A(2015).
- Sarungbam, J; Hakimi, AA; et al. TCEB1-Mutated Renal Cell Carcinoma (RCC): An Entity With Clear Cytoplasm and Prominent Fibromuscular Stroma Is Distinct From Clear Cell Renal Cell Carcinoma (ccRCC). LABORATORY INVESTIGATION 95:257A-257A(2015).
