TBX21
-
Official Full Name
T-box 21 -
Overview
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. [provided by RefSeq, Jul 2008] -
Synonyms
TBX21;T-box 21;TBET;T-PET;T-bet;TBLYM;T-box transcription factor TBX21;T-box protein 21;T-box expressed in T cells;transcription factor TBLYM;T-cell-specific T-box transcription factor T-bet
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Rat
- E.coli
- Mammalian Cell
- Mammalian cells
- HEK293T
- HEK293
- His
- GST
- His&T7
- Non
- Flag
- Myc&DDK
- His&Fc&Avi
Involved Pathway
TBX21 involved in several pathways and played different roles in them. We selected most pathways TBX21 participated on our site, such as Inflammatory bowel disease (IBD), which may be useful for your reference. Also, other proteins which involved in the same pathway with TBX21 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Inflammatory bowel disease (IBD) | HLA-DRB5,IL5,IL12B,IL22,Il23a; Il12b,HLA-DRB1,SMAD3,IL4R,TGFB1,TGFB3 |
Protein Function
TBX21 has several biochemical functions, for example, transcription factor activity, sequence-specific DNA binding,transcription regulatory region DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TBX21 itself. We selected most functions TBX21 had, and list some proteins which have the same functions with TBX21. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription regulatory region DNA binding | FOXC2,NCOR1,TFAP2A,TBL1XR1,BRCA1,SIX1,SMAD7,TNF,IKZF3,AIRE |
| transcription factor activity, sequence-specific DNA binding | RXRBA,MNX2A,FOXG1,ZIM3,TBPL2,IKZF1,ZFY1,ZNF773,MAFGA,DMRT2B |
Interacting Protein
TBX21 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TBX21 here. Most of them are supplied by our site. Hope this information will be useful for your research of TBX21.
EXOC5
Resources
Research Area
Multiple Sclerosis and Myelin Related Moleculesgamma delta T Cells
Natural Killer T (NKT) Cells
T Cell Cytokine Signaling
Th1 Cells
Related Services
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References
- Oakley, MS; Sahu, BR; et al. T-bet modulates the antibody response and immune protection during murine malaria. EUROPEAN JOURNAL OF IMMUNOLOGY 44:2680-2691(2014).
- Wu, SY; Zhao, HJ; et al. GTS-21, an alpha 7-nicotinic acetylcholine receptor agonist, modulates Th1 differentiation in CD4(+) T cells from patients with rheumatoid arthritis. EXPERIMENTAL AND THERAPEUTIC MEDICINE 8:557-562(2014).
