TBP

  • Official Full Name

    TATA binding protein

  • Overview

    General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1 with the rDNA promoter. SL1 is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA.

  • Synonyms

    TATA;binding protein TBP

Recombinant Proteins

  • Human
  • Cynomolgus
  • Zebrafish
  • Mouse
  • Chicken
  • E.coli
  • Mammalian Cells
  • HEK293
  • GST
  • His
  • T7
  • Non
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
TBP-1169H Active Recombinant Human TATA Box Binding Protein, GST-tagged E.coli Human GST
TBP-1005C Recombinant Cynomolgus TBP Protein, His-tagged Mammalian Cells Cynomolgus His
TBP-10448Z Recombinant Zebrafish TBP Mammalian Cells Zebrafish His
TBP-16517M Recombinant Mouse TBP Protein Mammalian Cells Mouse His
Tbp-1823M Recombinant Mouse Tbp protein, His & T7-tagged E.coli Mouse His&T7 Pro8~Thr316
TBP-30154TH Recombinant Human TBP, His-tagged E.coli Human His Full L.
TBP-6660C Recombinant Chicken TBP Mammalian Cells Chicken His
TBP-1210HCL Recombinant Human TBP 293 Cell Lysate HEK293 Human Non
TBP-6401H Recombinant Human TBP Protein (Met1-Thr338), N-His tagged E.coli Human His Met1-Thr338
TBP-748C Recombinant Cynomolgus Monkey TBP Protein, His (Fc)-Avi-tagged HEK293 Cynomolgus Avi&Fc&His
TBP-748C-B Recombinant Cynomolgus Monkey TBP Protein Pre-coupled Magnetic Beads HEK293 Cynomolgus
TBP-9051M Recombinant Mouse TBP Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
TBP-9051M-B Recombinant Mouse TBP Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    TBP involved in several pathways and played different roles in them. We selected most pathways TBP participated on our site, such as Basal transcription factors,Huntingtons disease,HTLV-I infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with TBP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Viral carcinogenesis KAT2A,HDAC10,PKM,EGR3,CDC20,CCNE2,EIF2AK2,ACTN4,HIST2H4A,PIK3CD
    Herpes simplex infection PILRA,CDK1,IRF9,EEF1D,TYK2,CDC34,PPP1CBL,TAF3,IKBKB,PVRL2
    Epstein-Barr virus infection SPI1,IKBKB,HLA-DRB3,DDX58,PSMD7,TRAF6,HLA-DQA1,GTF2E2,RELA,PRKACG
    Huntingtons disease DNAL4,NDUFS8,ATP5J,DNAH14,TFAM,NDUFA2,GRIN2B,NDUFB2,NDUFB8,SDHA
    Basal transcription factors GTF2A1L,TAF15,GTF2E1,TAF5L,GTF2F2,TAF9,GTF2F1,ERCC3,TBPL1,TAF3
    HTLV-I infection IL2RA,PPP3R1,VDAC3,PRKACA,WNT16,CRTC1,LTA,TNF,CDC16,SLC2A1

    Protein Function

    TBP has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding,RNA polymerase II repressing transcription factor binding,enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TBP itself. We selected most functions TBP had, and list some proteins which have the same functions with TBP. You can find most of the proteins on our site.

    Function Related Protein
    transcription factor binding REST,ZFPM1,LEF1,KAT6B,GATA6,TRERF1,NLK,MAFB,APBB1,STK4
    protein binding ISG15,TRIP12,AMFR,NPC1,STK16,THOC7,PPP1R12B,EEF1G,RBM22,KLKB1
    enzyme binding RFC5,MAPT,MSH2,AXIN1,LDB2,TSPAN10,DNM2,HSPA8,PGR,SNRPD3
    repressing transcription factor binding ARNTL,TCF3,CTBP1,DDX20,NFYB,HDAC4,CBX5,PARK7,MYC,KAT5
    transcription regulatory region DNA binding SALL4,ZNF821,STAT3,GRHL1,FOXI1,GATA6,NCOR1,HNF4A,ASH2L,NR1D1
    RNA polymerase II core promoter proximal region sequence-specific DNA binding MYBL1,ETV4,RAX,IFI203,PRDM5,BATF,MIXL1,SMAD2,TCF3,SREBF2
    transcription factor activity, sequence-specific DNA binding MEOX2,SALL3,HOXC8A,ZFP161,NR6A1B,DMRT3A,NR1I3,SIX1B,ZSCAN2,ZNF174
    RNA polymerase II repressing transcription factor binding MKKS,BBS2,MTA1,BBS7,BBS4,GSC,RBPJ,MTA2,TTC8,MIXL1

    Interacting Protein

    TBP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TBP here. Most of them are supplied by our site. Hope this information will be useful for your research of TBP.

    lt_sv40;TAF1;TAF5;TAF1B

    Resources

    References

    • Jackisch, C; Welslau, M; et al. Impact of trastuzumab treatment beyond disease progression for advanced/metastatic breast cancer on survival - Results from a prospective, observational study in Germany. BREAST 23:603-608(2014).
    • Voss, C; Schmitt, B; et al. A novel, non-radioactive eukaryotic in vitro transcription assay for sensitive quantification of RNA polymerase II activity. BMC MOLECULAR BIOLOGY 15:-(2014).

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