TBC1D1
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Official Full Name
TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 -
Overview
TBC1D1 is the founding member of a family of proteins sharing a 180- to 200-amino acid TBC domain presumed to have a;role in regulating cell growth and differentiation. These proteins share significant homology with TRE2 (USP6; MIM;604334), yeast Bub2, and CDC16 (MIM 603461) (White et al., 2000 (PubMed 10965142)). -
Synonyms
TBC1D1;TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1;TBC1 domain family member 1;KIAA1108;TBC;TBC1
Recombinant Proteins
- Human
- Rhesus macaque
- Chicken
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- Mammalian cells
- HEK293T
- His
- Non
- Flag
- Myc&DDK
- His&Fc&Avi
Involved Pathway
TBC1D1 involved in several pathways and played different roles in them. We selected most pathways TBC1D1 participated on our site, such as AMPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TBC1D1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| AMPK signaling pathway | G6PC,PRKAG1,PPP2R5E,ULK1,LIPE,CCNA2,PPP2R5D,PPP2R3A,ACACB,EEF2K |
Protein Function
TBC1D1 has several biochemical functions, for example, GTPase activator activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TBC1D1 itself. We selected most functions TBC1D1 had, and list some proteins which have the same functions with TBC1D1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTPase activator activity | ECT2,TBC1D9,GIT1,RALBP1,RGS4,AGFG1A,AGAP2,TBC1D7,ARHGAP15,TBC1D10C |
| protein binding | RNF13,PRRG2,ZNF133,RORB,AP5Z1,SLC25A23,TRAF3,TMEM88,SHC3,NUP205 |
Interacting Protein
TBC1D1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TBC1D1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TBC1D1.
YWHAG;HSPB1;SMAD2;UBE2E2;pi3p;BMH1;YWHAB;ROR1;YWHAH;GCG
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References
- Li, Z; Ni, CL; et al. Liraglutide enhances glucose transporter 4 translocation via regulation of AMP-activated protein kinase signaling pathways in mouse skeletal muscle cells. METABOLISM-CLINICAL AND EXPERIMENTAL 63:1022-1030(2014).
- Ducommun, S; Wang, HY; et al. Thr(649)Ala-AS160 knock-in mutation does not impair contraction/AICAR-induced glucose transport in mouse muscle. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 302:E1036-E1043(2012).
