TAC3
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Official Full Name
tachykinin 3 -
Overview
This gene encodes a member of the tachykinin family of secreted neuropeptides. The encoded protein is primarily;expressed in the central and peripheral nervous system and functions as a neurotransmitter. This protein is the ligand;for the neurokinin-3 receptor. This protein is also expressed in the outer syncytiotrophoblast of the placenta and may;be associated with pregnancy-induced hypertension and pre-eclampsia. Mutations in this gene are associated with;normosmic hypogonadotropic hypogonadism. Alternate splicing results in multiple transcript variants. -
Synonyms
TAC3;tachykinin 3;neurokinin beta , neuromedin K , NKNB;tachykinin-3;NKB;ZNEUROK1;neuromedin K;gamma tachykinin 3;preprotachykinin B;NKNB;PRO1155
Recombinant Proteins
- Human
- Rat
- E.coli
- HEK293
- HEK293T
- GST
- His
- His&GST
- Non
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| TAC3-3093H | Recombinant Human TAC3, GST-tagged | E.coli | Human | GST | 1-121aa | |
| TAC3-29652TH | Recombinant Human TAC3, His-tagged | E.coli | Human | His | 105 amino acids |
|
| TAC3-29653TH | Recombinant Human TAC3, His-tagged | E.coli | Human | His | Full L. 17-121 a.a. |
|
| Tac3-5805R | Recombinant Rat Tac3 protein, His & GST-tagged | E.coli | Rat | His&GST | Gln29~Ala102 |
|
| TAC3-79H | Recombinant Human Tachykinin 3, His-tagged | E.coli | Human | His |
|
|
| TAC3-1287HCL | Recombinant Human TAC3 293 Cell Lysate | HEK293 | Human | Non |
|
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| TAC3-4009H | Recombinant Human TAC3 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
|
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| TAC3-6390H | Recombinant Human TAC3 Protein (Cys23-Glu121), N-His tagged | E.coli | Human | His | Cys23-Glu121 |
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Involved Pathway
TAC3 involved in several pathways and played different roles in them. We selected most pathways TAC3 participated on our site, such as Class A/1 (Rhodopsin-like receptors),G alpha (q) signalling events,GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with TAC3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Peptide ligand-binding receptors | EDNRAB,TAC2,NTS,NMU,SST,KEL,CCBP2,PROKR1,NMBB,SSTR1 |
| Signaling by GPCR | GPR77,ARHGAP4,OXGR1A.3,XK,OR52B4,RGS14,EDNRAB,GPR132B,PNOC,CRHB |
| GPCR ligand binding | EDN3,NPFFR2,NMUR1,CCR3,CCR1,ADM,GPR37B,PTHRP2,RHOL,RGR |
| Signal Transduction | ARHGAP11A,BCL9,RTN4A,ARHGAP32,TAGAP1,METAP1,RHOT1B,LINGO1B,RNF146,ARHGEF16 |
| Class A/1 (Rhodopsin-like receptors) | CX3CR1,OPN5,EDN2,XK,DRD2,S1PR1,GAL,CCL35.1,KEL,LPAR5A |
| GPCR downstream signaling | NMS,RLN2,SSTR2,TRIO,RGS11,OXGR1A.3,OXER1,ADM,OR7D2,RGS1 |
| Gastrin-CREB signalling pathway via PKC and MAPK | PROKR1,TRPC7,EDN1,GPR68,TAC1,GPR65,QRFPR,RGS19,OPN4.1,NMU |
| G alpha (q) signalling events | NPFFR2,CASR,CHRM3,TRIO,TAC1,CCK,PROKR1A,NPS,LPAR2B,ANXA1B |
Protein Function
TAC3 has several biochemical functions, for example, protein binding,receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TAC3 itself. We selected most functions TAC3 had, and list some proteins which have the same functions with TAC3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| receptor binding | PTPRD,CXCL10,FZD8,PVRL1B,EDA,SLC9A3R2,CNPY3,EHHADH,NPY,APOL2 |
| protein binding | NRXN1,APBA3,NIPBL,Aatk,NEK2,NUDT12,PRDM1,TIMP3,POP7,NOG |
Interacting Protein
TAC3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TAC3 here. Most of them are supplied by our site. Hope this information will be useful for your research of TAC3.
IKBKAP;PTN;UBR1;VOPP1;FEZ1;CCDC90B
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References
- Bahadory, F; Moore, KH; et al. Gene expression of nnuscarinic, tachykinin, and purinergic receptors in porcine bladder: comparison with cultured cells. FRONTIERS IN PHARMACOLOGY 4:-(2013).
- Mostafa, GA; Al-Ayadhi, LY; et al. The possible link between the elevated serum levels of neurokinin A and anti-ribosomal P protein antibodies in children with autism. JOURNAL OF NEUROINFLAMMATION 8:-(2011).
