SYT2

  • Official Full Name

    synaptotagmin II
  • Overview

    Synaptotagmins, like SYT2, are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in;the process of vesicular trafficking and exocytosis (Hilbush and Morgan, 1994 (PubMed 8058779)).
  • Synonyms

    SYT2;synaptotagmin II;synaptotagmin-2;Synaptotagmin 2;Synaptotagmin2;SynaptotagminII;SYT 2;Syt II;SYT2_HUMAN;SytII

Recombinant Proteins

  • Human
  • Mouse
  • Rhesus macaque
  • Rat
  • Mus musculus
  • E.coli
  • Mammalian Cells
  • HEK293
  • GST
  • His
  • DDK
  • Myc
  • Non
  • Flag
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
SYT2-3083H Recombinant Human SYT2, GST-tagged E.coli Human GST 1-60aa
SYT2-16334M Recombinant Mouse SYT2 Protein Mammalian Cells Mouse His
SYT2-35H Recombinant Human SYT2 protein, MYC/DDK-tagged HEK293 Human DDK&Myc
SYT2-4590R Recombinant Rhesus monkey SYT2 Protein, His-tagged Mammalian Cells Rhesus macaque His
SYT2-5880R Recombinant Rat SYT2 Protein Mammalian Cells Rat His
SYT2-646HCL Recombinant Human SYT2 lysate HEK293 Human Non
RFL10500MF Recombinant Full Length Mouse Synaptotagmin-2(Syt2) Protein, His-Tagged E.coli Mus musculus His Full L. Full Length (1-422)
RFL5129RF Recombinant Full Length Rat Synaptotagmin-2(Syt2) Protein, His-Tagged E.coli Rat His Full L. Full Length (1-422)
SYT2-1027HFL Recombinant Full Length Human SYT2 Protein, C-Flag-tagged Mammalian Cells Human Flag Full L.
SYT2-1913H Recombinant Human SYT2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
SYT2-2150H Recombinant Human SYT2 Protein, His (Fc)-Avi-tagged HEK293 Human Avi&Fc&His
SYT2-2150H-B Recombinant Human SYT2 Protein Pre-coupled Magnetic Beads HEK293 Human
SYT2-4406R Recombinant Rhesus Macaque SYT2 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
SYT2-4406R-B Recombinant Rhesus Macaque SYT2 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
Syt2-4938R Recombinant Rat Syt2 Full Length Transmembrane protein, His-tagged E.coli Rat His Full L. 1-422aa
SYT2-5539R Recombinant Rat SYT2 Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
SYT2-5539R-B Recombinant Rat SYT2 Protein Pre-coupled Magnetic Beads HEK293 Rat
Syt2-6259M Recombinant Mouse Syt2 Protein, Myc/DDK-tagged HEK293 Mouse DDK&Myc
SYT2-8927M Recombinant Mouse SYT2 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
SYT2-8927M-B Recombinant Mouse SYT2 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    SYT2 involved in several pathways and played different roles in them. We selected most pathways SYT2 participated on our site, such as Disease,Infectious disease,Neurotoxicity of clostridium toxins, which may be useful for your reference. Also, other proteins which involved in the same pathway with SYT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Disease KPNA5,CCNC,CPSF6,ANTXR2,OS9,TCEB3,SFTPB,CDK8,EPM2A,HEYL
    Neurotoxicity of clostridium toxins STX1B
    Uptake and actions of bacterial toxins PDCD6IP,ANTXR1,ANTXR2
    Infectious disease VPS37A,CPSF4,IPO5,STX1B,KPNA5,PPIAL4A,DOCK2,KPNA4,EEF2,LTF

    Protein Function

    SYT2 has several biochemical functions, for example, calcium ion binding,calcium-dependent phospholipid binding,clathrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SYT2 itself. We selected most functions SYT2 had, and list some proteins which have the same functions with SYT2. You can find most of the proteins on our site.

    Function Related Protein
    calcium-dependent phospholipid binding SYT7B,SYTL2,SYT7,ANXA11B,SYT15,SYT17,PCLO,C2CD4B,ANXA11A,ANXA1B
    clathrin binding PICALMB,SMAP1,SYT4,SYT11,SYT11A,SYT17,SYT9B,AFTPH,SYT12,SYT5A
    protein binding NME4,LNX1,CD46,LNX2B,MAL2,HMG20B,CTAG1A,C20orf20,PDLIM5,P4HA2
    inositol 1,3,4,5 tetrakisphosphate binding ADAP2,ADAP1,ITPR3,AKR1C1
    calcium ion binding ANXA7,TESCB,PCDH1G2,CAPSLA,PCDH1A3,ANXA1,LCP1,ZZEF1,ALOX8,PLCH1
    syntaxin binding STXBP4,GOLGA2,TXLNG,VPS52,SYT9B,VAMP7,STXBP3,SYT5A,SYT11A,SYT1A

    Interacting Protein

    SYT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SYT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SYT2.

    HTT;PAUF;TGOLN2;PRKD2

    Resources

    References

    • Neumann, S; Haverkamp, S; et al. Characterization of small-field bistratified amacrine cells in macaque retina labeled by antibodies against synaptotagmin-2. JOURNAL OF COMPARATIVE NEUROLOGY 521:709-724(2013).
    • Monterrat, C; Boal, F; et al. Synaptotagmin 8 is expressed both as a calcium-insensitive soluble and membrane protein in neurons, neuroendocrine and endocrine cells. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1763:73-81(2006).
    • HILBUSH, BS; MORGAN, JI; et al. A 3RD SYNAPTOTAGMIN GENE, SYT3, IN THE MOUSE. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 91:8195-8199(1994).

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