SUV39H2
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Official Full Name
suppressor of variegation 3-9 homolog 2 -
Overview
Histone-lysine N-methyltransferase SUV39H2 is an enzyme that in humans is encoded by the SUV39H2 gene. -
Synonyms
SUV39H2;suppressor of variegation 3-9 homolog 2 (Drosophila);histone-lysine N-methyltransferase SUV39H2;FLJ23414;KMT1B;H3-K9-HMTase 2;su(var)3-9 homolog 2;lysine N-methyltransferase 1B;histone H3-K9 methyltransferase 2
Recombinant Proteins
- Human
- Mouse
- Chicken
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- Avi
- Fc
Involved Pathway
SUV39H2 involved in several pathways and played different roles in them. We selected most pathways SUV39H2 participated on our site, such as Lysine degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with SUV39H2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Lysine degradation | AGPHD1,EHHADH,SUV420H2,SETD1B,HADHA,COLGALT2,BBOX1,MLL1,ALDH1B1,NSD1 |
Protein Function
SUV39H2 has several biochemical functions, for example, histone methyltransferase activity (H3-K9 specific),protein binding,transcription regulatory region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SUV39H2 itself. We selected most functions SUV39H2 had, and list some proteins which have the same functions with SUV39H2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| zinc ion binding | SPG7,RNF222,TRIM55A,GLO1,LHX3,TRIM35-19,HERC2,C6AST1,RNF181,ANPEP |
| transcription regulatory region sequence-specific DNA binding | ARNTL,SIN3A,FOXN1,NFKB1,MEF2AA,FOXJ1,HIF1AL,NR5A1,ARNTL1A,NR5A5 |
| protein binding | KIF14,PSIP1,METAP2,MTOR,KCTD1,KCNG3,TBC1D5,PLCB1,THOP1,WBSCR27 |
| histone methyltransferase activity (H3-K9 specific) | SETDB2,SUV39H1,EHMT2,EHMT1 |
Interacting Protein
SUV39H2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SUV39H2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SUV39H2.
APPL2;PNMA1;HEL25;CEP70;RASSF1;PHF19;KCTD17;KLHDC4
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References
- Kudithipudi, S; Kusevic, D; et al. Non-radioactive Protein Lysine Methyltransferase Microplate Assay Based on Reading Domains. CHEMMEDCHEM 9:554-559(2014).
- Rice, JC; Briggs, SD; et al. Histone methyltransferases direct different degrees of methylation to define distinct chromatin domains. MOLECULAR CELL 12:1591-1598(2003).
