SUMF2

  • Official Full Name

    sulfatase modifying factor 2

  • Overview

    The catalytic sites of sulfatases are only active if they contain a unique amino acid, C-alpha-formylglycine (FGly). The FGly residue is posttranslationally generated from a cysteine by enzymes with FGly-generating activity. The gene described in this record is a member of the sulfatase-modifying factor family and encodes a protein with a DUF323 domain that localizes to the lumen of the endoplasmic reticulum. This protein has low levels of FGly-generating activity but can heterodimerize with another family member - a protein with high levels of FGly-generating activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

  • Synonyms

    SUMF2;sulfatase modifying factor 2;sulfatase-modifying factor 2;DKFZp566I1024;C alpha formyglycine generating enzyme 2;DKFZp66I1024;DKFZp686L17160;DKFZp781L1035;MGC99485;Paralog of the formylglycine generating enzyme;pFGE;SUMF 2;OTTHUMP00000159739;OTTHUMP00000208555;OTTHUMP00000208556;OTTHUMP00000208560;OTTHUMP00000208561;OTTHUMP00000208562;OTTHUMP00000208571;OTTHUMP00000209372;OTTHUMP00000209373;OTTHUMP00000209374;C-alpha-formyglycine-generating enzy

Recombinant Proteins

  • Human
  • Zebrafish
  • Mouse
  • E.coli
  • Mammalian Cells
  • Wheat Germ
  • HEK293
  • In Vitro Cell Free System
  • GST
  • His
  • Myc&DDK
  • Non
  • His&Fc&Avi
  • Flag
Cat.# Product name Source (Host) Species Tag Protein Length Price
SUMF2-3053H Recombinant Human SUMF2, GST-tagged E.coli Human GST N-term-221aa
SUMF2-1505Z Recombinant Zebrafish SUMF2 Mammalian Cells Zebrafish His
SUMF2-3054H Recombinant Human SUMF2 protein, GST-tagged Wheat Germ Human GST
SUMF2-3055H Recombinant Human SUMF2 protein, MYC/DDK-tagged HEK293 Human Myc&DDK
SUMF2-33H Recombinant Human SUMF2 protein, GST-tagged Wheat Germ Human GST 26 a.a. - 125 a.a.
SUMF2-35H Recombinant Human SUMF2 protein, MYC/DDK-tagged HEK293 Human Myc&DDK
SUMF2-865H Recombinant Human SUMF2 Mammalian Cells Human His
SUMF2-1345HCL Recombinant Human SUMF2 293 Cell Lysate HEK293 Human Non
SUMF2-4154H Recombinant Human SUMF2 Protein, His (Fc)-Avi-tagged HEK293 Human His&Fc&Avi
SUMF2-4154H-B Recombinant Human SUMF2 Protein Pre-coupled Magnetic Beads HEK293 Human
SUMF2-608HF Recombinant Full Length Human SUMF2 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 301 amino acids
Sumf2-6223M Recombinant Mouse Sumf2 Protein, Myc/DDK-tagged HEK293 Mouse Myc&DDK
SUMF2-9933HFL Recombinant Full Length Human SUMF2 protein, Flag-tagged Mammalian Cells Human Flag Full L.

    Involved Pathway

    SUMF2 involved in several pathways and played different roles in them. We selected most pathways SUMF2 participated on our site, such as Gamma carboxylation, hypusine formation and arylsulfatase activation,Glycosphingolipid metabolism,Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with SUMF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Metabolism of lipids and lipoproteins SACM1LB,MED25,COL4A3BP,INSIG2,AWAT2,CHKA,Alb,CYP4F22,CTGF,SLC25A20
    Post-translational protein modification ARSJ,B3GALTL,TMED10,B3GNT6,PPP6R3,MAGT1,DNAJC24,TRAPPC10,SCMH1,SAE1
    Sphingolipid metabolism ARSF,B4GALT6,CPTP,ASAH1,PPM1LA,SPTLC1,ASAH1B,GAL3ST1,PPM1L,KDSR
    Metabolism of proteins FURINA,IGFBP5A,THSD1,PHC3,TBCD,YIF1A,TRAPPC2L,NAT8B,SEMG1,GZMH
    Glycosphingolipid metabolism GLB1L,NEU3,ARSD,ARSF,ARSE,NEU4,ARSH,ARSK,ARSJ,GLTPD1
    The activation of arylsulfatases ARSI,ARSK,ARSJ,ARSF,ARSH
    Gamma carboxylation, hypusine formation and arylsulfatase activation WDR85,DOHH,F9B,DHPS,ARSI,ARSF,OTOP2,EIF5A2,ARSK,ARSD
    Metabolism FABP11B,AMDHD1,GPHN,ACOT2,HELZ2,NFYBB,CRYM,CDS1,THEM5,DUT

    Protein Function

    SUMF2 has several biochemical functions, for example, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SUMF2 itself. We selected most functions SUMF2 had, and list some proteins which have the same functions with SUMF2. You can find most of the proteins on our site.

    Function Related Protein
    metal ion binding CYP27C1,AMPD1,PPM1G,CDK15,GNA15,PICK1,KLF12B,MYLK,GNE,ZNF71

    Interacting Protein

    SUMF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SUMF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SUMF2.

    CACNA1A;ZFYVE9;ZDHHC17;FBXW7;env;H2AFX

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