SSTR5
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Official Full Name
somatostatin receptor 5 -
Overview
Somatostatin and its related peptide cortistatin exert multiple biological actions on normal and tumoral tissue targets by interacting with somatostatin receptors (SSTRs). The protein encoded by this gene is one of the SSTRs, which is a multi-pass membrane protein and belongs to the G-protein coupled receptor 1 family. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase, and different regions of this receptor molecule are required for the activation of different signaling pathways. A mutation in this gene results in somatostatin analog resistance. Alternatively spliced transcript variants have been identified in this gene. -
Synonyms
SSTR5;somatostatin receptor 5;somatostatin receptor type 5;somatostatin receptor subtype 5;SS-5-R
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Chicken
- Rat
- Mus musculus
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- His&Fc&Avi
Involved Pathway
SSTR5 involved in several pathways and played different roles in them. We selected most pathways SSTR5 participated on our site, such as Class A/1 (Rhodopsin-like receptors),G alpha (i) signalling events,GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with SSTR5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Peptide GPCRs | TAC4,SSTR1,CX3CR1,SSTR4,CXCR6 |
| GPCRs, Class A Rhodopsin-like | CX3CR1,CCR8,APLNR,CYSLTR1,GPR171,OPN1MW2,GPR50,LTB4R,OPN1SW,GPR31 |
| GPCR ligand binding | ADM2,HCAR1-2,NMS,PTH2,NMU,EMR1,DRD5,GPRC6A,RAMP3,CHRM5 |
| G alpha (i) signalling events | CCR8,PMCH,RGS1,ANXA1A,SSTR4,OPN5,RGS11,PENKB,RGS21,HCAR1-2 |
| Neuroactive ligand-receptor interaction | GABRR1,GRIK5,NPFFR1L3,GRM6A,F2RL2,GABRA4,TAAR8B,TRHR,Gh,LPAR6 |
| GPCR downstream signaling | PENKA,CCR7,GPR55A,ECT2,QRFPR,EDN2,AGTR2,OR7D2,NMS,ANXA1C |
| Class A/1 (Rhodopsin-like receptors) | PENKB,GPR18,GPR120,INSL5,GPR37L1,EDN3,AMCF-II,NPFF,SSTR4,HCRT |
| Peptide ligand-binding receptors | CCBP2,APLNR,UTS2D,EDN3,NMB,SST,UTS2,GAL,PROK1,GPR37B |
Protein Function
SSTR5 has several biochemical functions, for example, neuropeptide binding,somatostatin receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SSTR5 itself. We selected most functions SSTR5 had, and list some proteins which have the same functions with SSTR5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| somatostatin receptor activity | SSTR1,SSTR3,SSTR2,SSTR4 |
| neuropeptide binding | OPRD1A,NPY8AR,OPRK1,NPBWR2,OPRL1,SSTR2,OPRD1B,MRGPRX2,NPY8BR,MC4R |
Interacting Protein
SSTR5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SSTR5 here. Most of them are supplied by our site. Hope this information will be useful for your research of SSTR5.
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References
- Koc, EU; Ozgur, T; et al. Somatostatin Receptor 1 (SSTR1) and Somatostatin Receptor 5 (SSTR5) Expressions in Hepatocellular Carcinoma. HEPATO-GASTROENTEROLOGY 60:1693-1697(2013).
- Chinezu, L; Vasiljevic, A; et al. Expression of somatostatin receptors, SSTR2A and SSTR5, in 108 endocrine pituitary tumors using immunohistochemical detection with new specific monoclonal antibodies. HUMAN PATHOLOGY 45:71-77(2014).
