SRI
-
Official Full Name
sorcin -
Overview
Sorcin, also known as SRI, is a 22-kDa calcium-binding protein initially identified in multidrug-resistant cells. SRI modulates excitation-contraction coupling in the heart and contributes to calcium homeostasis in the heart sarcoplasmic reticulum. -
Synonyms
SRI;sorcin;22 kDa protein;Calcium binding protein amplified in mutlidrug resistant cells;CP 22;CP-22;CP22;SCN;Sorcin (class 4 gene);SORCN_HUMAN;V19;H_RG167B05.1;OTTHUMP00000161663;OTTHUMP00000205590;OTTHUMP00000206386;OTTHUMP00000213080;OTTHUMP00000225575;calcium binding protein amplified in mutlidrug-resistant cells
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Chicken
- Rhesus macaque
- Cynomolgus
- E.coli
- Mammalian Cell
- Insect Cell
- Insect Cells
- E. coli
- HEK293T
- HEK293
- His
- His&GST
- Non
- N-Twin strep and C-His&Flag
- Myc&DDK
- GST
- His&Fc&Avi
Involved Pathway
SRI involved in several pathways and played different roles in them. We selected most pathways SRI participated on our site, such as Ion channel transport,Stimuli-sensing channels,Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with SRI were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Transmembrane transport of small molecules | SLC39A2,WNK2,FLVCR1,TRPC4,SLC28A1,SLC35D1A,RHCGA,SLC2A10,SLC39A7,CUTC |
| Stimuli-sensing channels | TRPC4APB,TTYH2,TTYH3B,CLCA1,CLCNK,NHEDC1,MCOLN3,TRPC5,ASIC1A,SLC9A10 |
| Ion channel transport | TPCN1,CLCN2,ANO6,ATP1A1A.4,TTYH3,TRPC4APB,SLC17A3,TRDN,BEST1,CLCN4-2 |
Protein Function
SRI has several biochemical functions, for example, calcium channel regulator activity,calcium ion binding,calcium-dependent cysteine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SRI itself. We selected most functions SRI had, and list some proteins which have the same functions with SRI. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium ion binding | FBLN2,TMEM8C,DSG1,PVALB2,MMP20,FBLN1,CDH2,PSPH,CDHR3,NELL1 |
| protein binding | TRIM69,RRAS,GTPBP10,RPS7,FMO4,FMNL1,ATP6AP2,MYL12B,PSMA2,WIBG |
| identical protein binding | TMEM173,TPCN1,AGXT2L1,GOT2,APLP2,NIF3L1,ZHX2,ALAD,AXIN1,RGMB |
| protease binding | TP53,FURIN,FLOT2,ECM1,Casp3,SERPINE1,DERL1,ALPI,BRCA2,PYCARD |
| receptor binding | CAV1,F7,PVRL1B,TENC1,HILPDA,GSTK1,CXADR,ENSA,LTB,CLCF1 |
| protein heterodimerization activity | Bcl2a1b,HIST1H2AL,AHR,PDSS1,HYPM,ADORA2A,ITGB1A,ZHX3,KCNH5,IRAK1 |
| calcium channel regulator activity | NRXN3,HPCAL4,NRXN2,GRM7,PRKCB,GRM6A,STIM1A,PRKG1,TSPAN13A,CACNB2 |
| calcium-dependent cysteine-type endopeptidase activity | PDCD6,CAPN5A,CAPN9,CAPN11,CAPN2B,CAPN2A,CAPNS1A,CAPN10,CAPNS1,CAPNS1B |
| ion channel binding | CDH5,PHPT1,AKAP6,CTNNB1,CIB1,PDE4D,LYN,CALM2,PIRT,YWHAH |
Interacting Protein
SRI has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SRI here. Most of them are supplied by our site. Hope this information will be useful for your research of SRI.
CALCOCO2;PDE4C;TCF12;PRR13;PSEN2;VCAM1;STAT3
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