SREBF2
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Official Full Name
sterol regulatory element binding transcription factor 2 -
Overview
This gene encodes a ubiquitously expressed transcription factor that controls cholesterol homeostasis by stimulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain. -
Synonyms
SREBF2;sterol regulatory element binding transcription factor 2;sterol regulatory element-binding protein 2;bHLHd2;SREBP2;AI608257;Class D basic helix-loop-helix protein 2;OTTHUMP00000028740;Processed sterol regulatory element-binding protein 2;SRBP2_HUMAN;SREBF 2;SREBF2 protein;SREBP 2;SREBP-2;SREBP2gc;sterol regulatory element binding factor 2;Sterol regulatory element binding protein 2;Sterol regulatory element-binding transcription factor 2
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Rat
- Mus musculus
- zebrafish
- Cricetulus griseus
- Xenopus laevis
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- GST
- His
- Non
- Avi
- Fc
Involved Pathway
SREBF2 involved in several pathways and played different roles in them. We selected most pathways SREBF2 participated on our site, such as Activation of gene expression by SREBF (SREBP),Cholesterol biosynthesis,Developmental Biology, which may be useful for your reference. Also, other proteins which involved in the same pathway with SREBF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Developmental Biology | EFNB2,LGI1B,GFRA2,ITGB3A,CCNC,COL9A3,DUSP9,PAQR3B,ARPC5,NR5A1 |
| Activation of gene expression by SREBF (SREBP) | NCOA2,CYP51A1,NFYBB,NFYBA,PMVK,MTF1,DHCR7,CREBBP,CARM1,HELZ2 |
| Cholesterol biosynthesis | CYP51A1,DHCR7,DHCR24,LBR,PMVK,ARV1,EBP |
| Metabolism of lipids and lipoproteins | SUMF2,SIN3B,INSIG2,CYP2Y3,APOA4B.2,ACOT11A,ARSJ,MED19,MED21,PNPLA8 |
| PPARA activates gene expression | MED18,MED20,MED26,MED21,MTF1,MED10,MED15,MED8,MED31,MED7 |
| Metabolism | DPYS,KCNS3,PFKLB,APOEB,CYP2K16,D2HGDH,SLC25A20,KCNJ11,AKR1C2,ACOT13 |
| Fatty acid, triacylglycerol, and ketone body metabolism | GRHL1,ACOT2,PPARGC1B,SLC25A1A,ELOVL1A,G0S2,YAP1,SIN3B,AGPAT2,MED9 |
| Regulation of cholesterol biosynthesis by SREBP (SREBF) | DHCR7,NFYAL,NFYBA,MTF1,INSIG1,NFYBB,INSIG2,YY2,PMVK |
Protein Function
SREBF2 has several biochemical functions, for example, NOT C-8 sterol isomerase activity,E-box binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SREBF2 itself. We selected most functions SREBF2 had, and list some proteins which have the same functions with SREBF2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | ZNF460,HOXA2,ELK1,NFATC3,MYPOP,KLF5,ALS2CR8,TFAP2A,MEF2A,TFAM |
| protein binding | SLC6A20,RIPPLY2,AK3,GINS2,AIFM1,FAM162A,SKP1,SIRT3,EDDM3B,CLPX |
| protein dimerization activity | TFE3B,NEUROD6B,HES2.2,MYCLB,EBF1,MYC,TFAP2B,PPP3CA,GPR139,PTF1A |
| transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding | POU4F2,SNAI1,GCFC2,PROX1A,ATF3,FOXO1,ZNF148,NFATC2,MXD1,NACC2 |
| protein C-terminus binding | PEX10,PEX26,OPRL1,ECM1,PFKM,PICK1,PPM1A,PIAS4,VGLL2,RAD51 |
| E-box binding | ASCL2,TAL1,PER1,TCF3,NEUROD1,C1orf51,ARNTL,MYC,BHLHE40,CLOCK |
Interacting Protein
SREBF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SREBF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SREBF2.
SP1;HNF4A;TP53;ldlr_human_sre_dna-probe;Kpnb1;HNF4A;SMAD3;b3kqf8_human;ABLIM1;PIAS1;PIAS2;HSPA5
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References
- Khaidakov, M; Mitra, S; et al. Oxidized LDL Receptor 1 (OLR1) as a Possible Link between Obesity, Dyslipidemia and Cancer. PLOS ONE 6:-(2011).
- Barderas, R; Babel, I; et al. An optimized predictor panel for colorectal cancer diagnosis based on the combination of tumor-associated antigens obtained from protein and phage microarrays. JOURNAL OF PROTEOMICS 75:4647-4655(2012).
- Babel, I; Barderas, R; et al. Identification of MST1/STK4 and SULF1 Proteins as Autoantibody Targets for the Diagnosis of Colorectal Cancer by Using Phage Microarrays. MOLECULAR & CELLULAR PROTEOMICS 10:-(2011).
