SPI1

  • Official Full Name

    spleen focus forming virus (SFFV) proviral integration oncogene spi1

  • Overview

    This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell;development. The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of;target genes, and regulates their expression in coordination with other transcription factors and cofactors. The;protein can also regulate alternative splicing of target genes. Multiple transcript variants encoding different;isoforms have been found for this gene.

  • Synonyms

    SPI1;spleen focus forming virus (SFFV) proviral integration oncogene spi1;transcription factor PU.1;31 kDa transforming protein;hematopoietic transcription factor PU.1;OF;PU.1;SFPI1;SPI 1;SPI 1 proto oncogene;SPI A;SPI-1 proto-oncogene;31 kDa-transforming protein;SPI-1;SPI-A

Recombinant Proteins

  • Human
  • Rat
  • Chicken
  • Mouse
  • E.coli
  • Mammalian Cells
  • HEK293
  • His
  • Non
  • His&Myc
  • Avi&Fc&His
Cat.# Product name Source (Host) Species Tag Protein Length Price
SPI1-172H Recombinant Human SPI1 protein, His-tagged E.coli Human His
SPI1-173H Recombinant Human SPI1 protein, His-tagged E.coli Human His
SPI1-5706R Recombinant Rat SPI1 Protein Mammalian Cells Rat His
SPI1-6580C Recombinant Chicken SPI1 Mammalian Cells Chicken His
SPI1-1683HCL Recombinant Human SPI1 cell lysate Human Non
Spi1-4533M Recombinant Mouse Spi1 protein, His&Myc-tagged E.coli Mouse His&Myc 1-272a.a.
SPI1-5365R Recombinant Rat SPI1 Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
SPI1-5365R-B Recombinant Rat SPI1 Protein Pre-coupled Magnetic Beads HEK293 Rat

    Involved Pathway

    SPI1 involved in several pathways and played different roles in them. We selected most pathways SPI1 participated on our site, such as Osteoclast differentiation,HTLV-I infection,Epstein-Barr virus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with SPI1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Acute myeloid leukemia PML,CHUK,PIK3CG,MAP2K2,PPARD,AKT3,PIM1,ARAF,TCF7,PIK3CD
    Osteoclast differentiation ACP5,NFKB1,CYBA,PPP3CA,TNFRSF1A,PPP3CC,NCF1,FCGR1,SYK,NCF2
    HTLV-I infection KRAS,TNFRSF13C,WNT3A,PIK3CA,CCNB2,IL15,CD3G,ANAPC2,SRF,WNT8A
    Pathways in cancer CSF1R,GNG3,Ar,FIGF,CASP8,WNT9A,GNG4,TCEB2,XIAP,PIK3CA
    Epstein-Barr virus infection PIK3R2,PSMD13,IRF3,VIM,POLR3G,NFKBIE,RAN,STAT3,EIF2AK1,RBPJ
    Transcriptional misregulation in cancer RUNX2,ITGB7,FLI1,ERG,ELK4,IL2RB,BCL2L1,CCNT1,EYA1,NTRK1

    Protein Function

    SPI1 has several biochemical functions, for example, NFAT protein binding,RNA binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SPI1 itself. We selected most functions SPI1 had, and list some proteins which have the same functions with SPI1. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II transcription factor activity, sequence-specific DNA binding FOXD2,TFDP2,FOXJ1A,FOXN2B,ATF5,JUNBB,ZNF446,FOXK1,SP1,ERG
    RNA binding TROVE2,HNRPL,RPS3,HNRNPL,MIF4GDB,PRAC,SNRPA,RAVER2,ENDOU,FMR1
    transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding TFAP2C,DLX4,HOXA2,CTCF,TCF21,JDP2,SALL1,DACH1,HELT,HES1
    transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding NFKB1,NFE2L1,BACH1,TARDBP,FUBP1,HMGA1,ARID3B,SIX3,CUX1,RELA
    RNA polymerase II transcription factor binding ANKRD1,MEF2A,CHST13,CREBBP,GATA2,ZGLP1,MTDH,GATA2A,TRP53,GATA2B
    RNA polymerase II distal enhancer sequence-specific DNA binding ARX,SOX10,NONO,MIXL1,H2AFZ,NR2F6,CDX1,BACH2,FLI1,POU4F1
    transcription factor activity, sequence-specific DNA binding HSFX1,ZFP628,TBX5A,BSX,GTF2I,ZNF668,RORAB,TFDP2,TBX19,HIVEP3
    NFAT protein binding MAPK14,SFPI1,GATA4,PPARA,FOXP3
    RNA polymerase II core promoter sequence-specific DNA binding RBPJ,H3F3B,YAP1,SMAD1,MITF,PAX6,TCF7L2,SOX8,SMAD5,GATA3

    Interacting Protein

    SPI1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SPI1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SPI1.

    PML-RAR

    Resources

    Research Area

    Hematopoietic Stem Cell Markers
    Hematopoietic Stem Cell Transcription Factors and Regulators
    Plasmacytoid Dendritic Cells
    B Cell Transcription Factors
    Th9 Cells
    Dendritic Cell Development

    References

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