SOX9
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Official Full Name
SRY (sex determining region Y)-box 9 -
Overview
The protein encoded by this gene recognizes the sequence CCTTGAG along with other members of the HMG-box class DNA-binding proteins. It acts during chondrocyte differentiation and, with steroidogenic factor 1, regulates transcription of the anti-Muellerian hormone (AMH) gene. Deficiencies lead to the skeletal malformation syndrome campomelic dysplasia, frequently with sex reversal. [provided by RefSeq, Jul 2008] -
Synonyms
SOX9;SRY (sex determining region Y)-box 9;CMD1;SRA1;CMPD1;transcription factor SOX-9;SRY-related HMG-box, gene 9;SRY (sex-determining region Y)-box 9 protein
Recombinant Proteins
- Human
- Rhesus macaque
- Chicken
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- Yeast
- In Vitro Cell Free System
- GST
- Non
- His
- Flag
- Avi
- Fc
- DDK
- Myc
Involved Pathway
SOX9 involved in several pathways and played different roles in them. We selected most pathways SOX9 participated on our site, such as cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SOX9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| cAMP signaling pathway | BRAF,RHOA,HTR6,FOS,VAV1,PPP1CC,ACOX3,Adcy4,BAD,PLN |
Protein Function
SOX9 has several biochemical functions, for example, bHLH transcription factor binding,beta-catenin binding,chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SOX9 itself. We selected most functions SOX9 had, and list some proteins which have the same functions with SOX9. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | BAG6,PPP1CB,KRTAP4-11,SNF8,EPB42,URI1,PHF19,C17orf62,ACAN,PTBP1 |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | TTC6,ZFP292,RELA,NEUROD6,CEBPA,MYBL1,SFPI1,FOSB,TFE3B,NRF1 |
| core promoter sequence-specific DNA binding | SP1,GATA3,MEOX1,NR1D1,PPARG,H2AFY,ZFP750,SOHLH1,ATF4,TRP53 |
| enhancer sequence-specific DNA binding | TBX19,KLF6A,GATA1,FOXN4,HMGB2,SOX11,YY1,GATA5,GATA3,KLF7B |
| beta-catenin binding | SHROOM2,APC,DACT1,PTPRJ,GLI3,C,TCF7L1B,SALL1,CDH1,TBL1XR1 |
| transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | NR1H4,ATF2,SFPI1,MYF6,PURA,NFIX,PKNOX1,NKX2-5,THRA,MYF5 |
| chromatin binding | SKI,KIAA0101,MEIOB,WDHD1,MCM5,NCAPD3,HMGB2B,TCF7L1A,TCF3,NR5A5 |
| bHLH transcription factor binding | BHLHE40,SMAD3,MAP3K10,SP1,TCF21,SIRT1,FOXH1,RUNX2,TCF3A,EP300 |
| protein kinase A catalytic subunit binding | GSK3B,PRKAR1B,RYR2,GSK3A,CSK,PKIA,KCNQ1,EZR,PRKAR1A,PJA2 |
Interacting Protein
SOX9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SOX9 here. Most of them are supplied by our site. Hope this information will be useful for your research of SOX9.
ATP6V1H;dsdna_dadt:dadt
Resources
Research Area
Pancreatic Progenitor Cell Transcription FactorsChondrogenesis Markers
Cancer Stem Cell Transcription Factors
Epithelial Stem Cell Transcription Factors
Hepatic and Pancreatic Progenitor Cell Transcription Factors
Mesenchymal Stem Cell Transcription Factors
Neural Stem Cell Transcription Factors
Intestinal Stem Cell Markers
Neural Stem Cell Markers
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References
