SOX6
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Official Full Name
SRY (sex determining region Y)-box 6 -
Overview
This gene encodes a member of the D subfamily of sex determining region y-related transcription factors that are characterized by a conserved DNA-binding domain termed the high mobility group box and by their ability to bind the minor groove of DNA. The encoded protein is a transcriptional activator that is required for normal development of the central nervous system, chondrogenesis and maintenance of cardiac and skeletal muscle cells. The encoded protein interacts with other family members to cooperatively activate gene expression. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009] -
Synonyms
SOX6;SRY (sex determining region Y)-box 6;SOXD;HSSOX6;transcription factor SOX-6;SRY-box containing gene 6
Recombinant Proteins
- Human
- Zebrafish
- Rat
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- His
- Non
- DDK
- Myc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SOX6-3555H | Recombinant Human SOX6 protein, His-tagged | E.coli | Human | His | 272-828 aa | |
| SOX6-6616Z | Recombinant Zebrafish SOX6 | Mammalian Cells | Zebrafish | His |
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| SOX6-1557HCL | Recombinant Human SOX6 293 Cell Lysate | HEK293 | Human | Non |
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| Sox6-2090R | Recombinant Rat Sox6 Protein, His-tagged | E.coli | Rat | His | Met1-Pro266 |
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| SOX6-2721H | Recombinant Human SOX6 Protein, His-tagged | E.coli | Human | His | Met1-Pro269 |
|
| SOX6-2740H | Recombinant Human SOX6 protein(21-260 aa), C-His-tagged | E.coli | Human | His | 21-260 aa |
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| SOX6-5078H | Recombinant Human SOX6 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | DDK&Myc |
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| SOX6-5407H | Recombinant Human SOX6 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | DDK&Myc |
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| Sox6-6058M | Recombinant Mouse Sox6 Protein, Myc/DDK-tagged | HEK293 | Mouse | DDK&Myc |
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Involved Pathway
SOX6 involved in several pathways and played different roles in them. We selected most pathways SOX6 participated on our site, such as Deactivation of the beta-catenin transactivating complex,Endochondral Ossification,Signal Transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with SOX6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signaling by Wnt | BCL9L,ASH2L,AES,RSPO4,RNF43,KREMEN2,CSNK1G2,ZNRF3,SOX13,SOX9B |
| TCF dependent signaling in response to WNT | LGR6,CBY1,KREMEN1,SOX32,SOX9A,RSPO1,WIF1,PYGO2,RNF43,RSPO2 |
| Endochondral Ossification | IFT88,NKX3-2,SERPINH1,FRZB,CST5,CTSL2,RUNX3,RUNX2A,COL10A1A,SOX9A |
| Signal Transduction | GPR31,RGS20,STARD8,PLEKHG2,ARHGAP36,NMT1A,GPR177,AKR1C21,ROR2,RNF146 |
| Deactivation of the beta-catenin transactivating complex | ASH2L,SOX4B,SOX9B,PYGO1,RBBP5,PYGO2,BCL9L,SRY,SOX32,SOX9A |
Protein Function
SOX6 has several biochemical functions, for example, DNA binding,protein binding,protein heterodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SOX6 itself. We selected most functions SOX6 had, and list some proteins which have the same functions with SOX6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein heterodimerization activity | TOP2B,CRLF1,HIST1H3H,RRAGA,P4HB,HIST1H2BO,HIST1H4E,HOMER1,PDGFB,BCL2L1 |
| DNA binding | ZNF32,ARID2,THAP7,KAT6A,SIX4B,IKZF1,LHX8,POU5F1,BHLHE41,NFATC2 |
| transcription regulatory region DNA binding | XRCC6,ZFP513,ATF4,FOS,LEF1,GRHL1,CTNNB1,DDIT3,Ar,ZNF649 |
| sequence-specific DNA binding | IRX3B,HLX,RHOXF1,RARGB,HIVEP2,PAX3,ZNF148,CUX2,ISX,DLX3 |
| transcription factor activity, sequence-specific DNA binding | DMRTA1,NFE2L2B,POU5F2,TCF12,ZNF8,RUNX2,ZFY1,POU6F2,SIX1B,PCGF2 |
| protein binding | GSDMA2,CDX4,SLC25A4,TRAPPC6B,ZNF707,FBXW5,VPS45,RAB11A,IMP3,EYA1 |
Interacting Protein
SOX6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SOX6 here. Most of them are supplied by our site. Hope this information will be useful for your research of SOX6.
SHOX;POMGNT1;ZNF184
Resources
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References
- Rudrabhatla, P; Utreras, E; et al. Regulation of Sox6 by Cyclin Dependent Kinase 5 in Brain. PLOS ONE 9:-(2014).
- Amano, K; Hata, K; et al. Sox9 Family Members Negatively Regulate Maturation and Calcification of Chondrocytes through Up-Regulation of Parathyroid Hormone-related Protein. MOLECULAR BIOLOGY OF THE CELL 20:4541-4551(2009).
