SOAT1

  • Official Full Name

    sterol O-acyltransferase 1

  • Overview

    Acyl-coenzyme A:cholesterol acyltransferase (ACACT; EC 2.3.1.26) is an intracellular protein located in the endoplasmic reticulum that forms cholesterol esters from cholesterol. Accumulation of cholesterol esters as cytoplasmic lipid droplets within macrophages and smooth muscle cells is a characteristic feature of the early stages of atherosclerotic plaques (Cadigan et al., 1988

  • Synonyms

    SOAT1;sterol O-acyltransferase 1;SOAT, STAT, sterol O acyltransferase (acyl Coenzyme A: cholesterol acyltransferase) 1;ACAT;acyl Coenzyme A: cholesterol acyltransferase;ACAT-1;ACAT1;Acyl coenzyme A cholesterol acyltransferase 1;Acyl-coenzyme A:cholesterol acyltransferase 1;Cholesterol acyltransferase 1;SOAT;SOAT1_HUMAN;STAT;Sterol O acyltransferase 1;OTTHUMP00000033188;acyl-Coenzyme A: cholesterol acyltransferase;sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1;ACACT;RP11-215I23.2

Recombinant Proteins

  • Human
  • Mouse
  • Rat
  • Zebrafish
  • Cynomolgus
  • Macaca fascicularis
  • Mus musculus
  • Cricetulus griseus
  • Chlorocebus Aethiops
  • E.coli
  • Mammalian Cell
  • Wheat Germ
  • E.coli expression system
  • HEK293
  • GST
  • His
  • Non
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
SOAT1-2868H Recombinant Human SOAT1, GST-tagged E.coli Human GST 1-326aa
SOAT1-15741M Recombinant Mouse SOAT1 Protein Mammalian Cell Mouse His
SOAT1-31430TH Recombinant Human SOAT1 Wheat Germ Human Non 73 amino acids
SOAT1-5660R Recombinant Rat SOAT1 Protein Mammalian Cell Rat His
SOAT1-6662Z Recombinant Zebrafish SOAT1 Mammalian Cell Zebrafish His
SOAT1-955C Recombinant Cynomolgus SOAT1 Protein, His-tagged Mammalian Cell Cynomolgus His
SOAT1-1665HCL Recombinant Human SOAT1 cell lysate Human Non
RFL13920RF Recombinant Full Length Rat Sterol O-Acyltransferase 1(Soat1) Protein, His-Tagged E.coli expression system Rat His Full L. Full Length (1-545)
RFL1727MF Recombinant Full Length Macaca Fascicularis Sterol O-Acyltransferase 1(Soat1) Protein, His-Tagged E.coli expression system Macaca fascicularis His Full L. Full Length (1-550)
RFL17435MF Recombinant Full Length Mouse Sterol O-Acyltransferase 1(Soat1) Protein, His-Tagged E.coli expression system Mus musculus His Full L. Full Length (1-540)
RFL22146CF Recombinant Full Length Cricetulus Griseus Sterol O-Acyltransferase 1(Soat1) Protein, His-Tagged E.coli expression system Cricetulus griseus His Full L. Full Length (1-546)
RFL3494CF Recombinant Full Length Chlorocebus Aethiops Sterol O-Acyltransferase 1(Soat1) Protein, His-Tagged E.coli expression system Chlorocebus Aethiops His Full L. Full Length (1-550)
RFL8317HF Recombinant Full Length Human Sterol O-Acyltransferase 1(Soat1) Protein, His-Tagged E.coli expression system Human His Full L. Full Length (1-550)
SOAT1-5319R Recombinant Rat SOAT1 Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
SOAT1-5319R-B Recombinant Rat SOAT1 Protein Pre-coupled Magnetic Beads HEK293 Rat
SOAT1-698C Recombinant Cynomolgus Monkey SOAT1 Protein, His (Fc)-Avi-tagged HEK293 Cynomolgus His&Fc&Avi
SOAT1-698C-B Recombinant Cynomolgus Monkey SOAT1 Protein Pre-coupled Magnetic Beads HEK293 Cynomolgus
SOAT1-8562M Recombinant Mouse SOAT1 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
SOAT1-8562M-B Recombinant Mouse SOAT1 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    SOAT1 involved in several pathways and played different roles in them. We selected most pathways SOAT1 participated on our site, such as Steroid biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with SOAT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Steroid biosynthesis DHCR7,CEL.1,CELL,SQLEA,LIPA,MSMO1,Cel,FDFT1,FAXDC2,EBP

    Protein Function

    SOAT1 has several biochemical functions, for example, cholesterol O-acyltransferase activity,cholesterol binding,fatty-acyl-CoA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SOAT1 itself. We selected most functions SOAT1 had, and list some proteins which have the same functions with SOAT1. You can find most of the proteins on our site.

    Function Related Protein
    fatty-acyl-CoA binding GCDHA,ACBD4,ACADSB,IVD,PECI,ACOX2,ACBD3,ACOX3,ACOXL,ALDH6A1
    cholesterol binding OSBPL3,OSBPL2,APOD,APOA4A,ABCA1,APOEA,ERLIN2,APOA5,NR1H3,OSBPL10
    protein binding POLD2,WARS,SAE1,RARRES3,PHF16,TSSK6,HLA-A,POP5,MORN3,JAG2
    sterol O-acyltransferase activity CML2,MBOAT1,NAT14,CML5,HHAT,ACNAT2,MBOAT7,LPCAT3,Acnat1,MBOAT4

    Interacting Protein

    SOAT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SOAT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SOAT1.

    TERF1;UBIAD1;Ktn1;Sec24c;KATNA1;Eef1a1;CANX;Rab5c;Bmpr1a;RAB5C;RAB7A;RAB2A;RAB11A;CLTC;PKN2;Rmdn3;TMEM63B;C1qbp

    Resources

    Research Area

    Fatty Acid Synthesis

    References

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