SNRPA1
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Official Full Name
small nuclear ribonucleoprotein polypeptide A -
Overview
SNRPA1, also known as U2 small nuclear ribonucleoprotein A, is a component of the U2 snRNP that forms a complex with U2 snRNP B (U2B). Together, U2 snRNP A and U2 snRNP B form a complex that binds to the U2 snRNA hairpin IV. The configuration of this U2 The protein encoded by this gene associates with stem loop II of the U1 small nuclear ribonucleoprotein, which binds the 5' splice site of precursor mRNAs and is required for splicing. The encoded protein autoregulates itself by polyadenylation inhibition of its own pre-mRNA via dimerization and has been implicated in the coupling of splicing and polyadenylation. -
Synonyms
SNRPA1;small nuclear ribonucleoprotein polypeptide A;U2 small nuclear ribonucleoprotein A;Lea1;RU2A_HUMAN;U2 small nuclear ribonucleoprotein polypeptide A;U2 snRNP A;SNRPA;U1 small nuclear ribonucleoprotein A;Mud1;U1 A;U1A;U1 snRNP A;U1 snRNP-specific protein A;U1 small nuclear RNP-specific A;U1-A
Recombinant Proteins
- Human
- Zebrafish
- Chicken
- Rhesus macaque
- Mouse
- Cynomolgus
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- Mammalian cells
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
- Flag
Involved Pathway
SNRPA1 involved in several pathways and played different roles in them. We selected most pathways SNRPA1 participated on our site, such as Spliceosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with SNRPA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Spliceosome | RBM22,PRPF4,PRPF8,SF3A3,HNRNPU,TCERG1,HSPA1L,HNRPKL,PLRG1,SNRPE |
Protein Function
SNRPA1 has several biochemical functions, for example, U2 snRNA binding,poly(A) RNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SNRPA1 itself. We selected most functions SNRPA1 had, and list some proteins which have the same functions with SNRPA1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| poly(A) RNA binding | DZIP3,EIF3E,SURF6,RRP8,SRP19,SMNDC1,MRPS21,RPL24,MRPS5,NHP2 |
| U2 snRNA binding | PRPF8,ISG20,TROVE2 |
| protein binding | POLR3GL,VAC14,GLI3,SRI,UBXN6,PRKAR1A,HEY1,RBM41,TRAPPC3,LYL1 |
Interacting Protein
SNRPA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SNRPA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SNRPA1.
SNRPA;VCAM1;SNRPB2;TOP1;TRDMT1;SMNDC1;HNF1A;HLA-B;VHL;MAGEA6;CASP4;ARF6
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References
- Wood, JD; Liu, SM; et al. Anti-Enteric Neuronal Antibodies and the Irritable Bowel Syndrome. JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY 18:78-85(2012).
- Kaneko, Y; Suwa, A; et al. Clinical associations with autoantibody reactivities to individual components of U1 small nuclear ribonucleoprotein. LUPUS 19:307-312(2010).
