SMURF1
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Official Full Name
SMAD specific E3 ubiquitin protein ligase 1 -
Overview
Members of the transforming growth factor-beta (TGFB) family signal through type I and type II serine/threonine-kinase receptors,Which in turn activate the SMAD signaling pathway. Bone morphogenetic protein (BMP) receptors target SMAD1, SMAD5, and SMAD8,Whereas receptors for activin and TGFB (e.g., ACVR1 and TGFBR1, respectively) target SMAD2 and SMAD3. Phosphorylation of these receptor-regulated SMADs induces their association with the common-partner SMAD, SMAD4. Smurf1, a HECT domain E3 ubiquitin ligase, regulates cell polarity and protrusive activity and is required to maintain the transformed morphology and motility of a tumor cell. Atypical protein kinase C-zeta (PKC2), an effector of the Cdc42/Rac1-PAR6 polarity complex, recruits Smurf1 to cellular protrusions,Where it controlled the local level of RhoA. Smurf1 thus links the polarity complex to degradation of RhoA in lamellipodia and filopodia to prevent RhoA signaling during dynamic membrane movements. -
Synonyms
SMURF1;SMAD specific E3 ubiquitin protein ligase 1;E3 ubiquitin-protein ligase SMURF1;KIAA1625;hSMURF1;E3 ubiquitin ligase SMURF1;Smad-specific E3 ubiquitin ligase 1;Smad ubiquitination regulatory factor 1;SMAD-specific E3 ubiquitin-protein ligase 1
Recombinant Proteins
- Zebrafish
- Rhesus macaque
- Human
- Mouse
- Mammalian Cell
- E.coli
- Sf9 Insect Cell
- HEK293
- HEK293T
- His
- GST
- Flag
- Non
- Myc&DDK
- N-His-GST
- His&Fc&Avi
Involved Pathway
SMURF1 involved in several pathways and played different roles in them. We selected most pathways SMURF1 participated on our site, such as Ubiquitin mediated proteolysis,Endocytosis,TGF-beta signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMURF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| TGF-beta signaling pathway | SMAD6,LEFTY2,LFT2,RHOAC,AMH,ROCK1,RPS6KB1,BMPR1AB,BMPR2A,ACVR1 |
| Endocytosis | SH3GL1,FGFR3,HSP70,AMPH,ZFP652,SH3GLB1B,ARF6,DNM1B,EHD4,ARF3 |
| Ubiquitin mediated proteolysis | SIAH1A,UBE2E2,NEDD4,TCEB2,CBLC,TRAF6,BIRC3,KLHL9,HERC3,UBE2R2 |
Protein Function
SMURF1 has several biochemical functions, for example, I-SMAD binding,R-SMAD binding,activin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMURF1 itself. We selected most functions SMURF1 had, and list some proteins which have the same functions with SMURF1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ligase activity | RNF168,TTLL9,TRIM27,PIAS3,TRIM11,BTR22,MKRN1,LIPT2,TRIM33,MARCH2 |
| activin binding | SMAD7,ENG,FKBP1A,ACVRL1,ACVR2B,FST,ACVR1,TGFBR3,FSTL3 |
| protein binding | BNIP2,TMED1,TPI1,ILVBL,UNC13D,TTC8,RAB5B,ZNF572,GSE1,KDR |
| R-SMAD binding | MYOCD,AXIN1,C18orf1,PMEPA1,MEN1,TRIM33,JUN,SMAD4,SMAD3,PPM1A |
| ubiquitin protein ligase activity | PRPF19,UBE2G2,BRAP,UBE3B,HERC4,SIAH2L,UBE2H,SIAH1,CBLC,RBX1 |
| ubiquitin-protein transferase activity | ITCH,TRAF4,TRAF3,CNOT4,MYCBP2,SIAH1,UBE3A,RNF10,PAX6,RNF11 |
| I-SMAD binding | SMAD7,TGFBR1,SMAD1,AXIN2,AXIN1,SMAD6,CTNNB1,SMAD2,TGFB1I1,SMAD4 |
| phospholipid binding | PRKCI,BAIAP2L2,PSD2,BAD,NBEA,ARHGAP26,PACSIN1,MYOF,NBEAL2,SERPINB1A |
Interacting Protein
SMURF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMURF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMURF1.
FBXL15;PLEKHO1;PSME3;SMAD1;KLF2;UBA1;UBE2N;UBE2V1
SMURF1 Related Signal Pathway
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