SMARCC2
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Official Full Name
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 -
Overview
The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and contains a predicted leucine zipper motif typical of many transcription factors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] -
Synonyms
SMARCC2;SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2;Rsc8;BAF170;CRACC2;SWI/SNF complex subunit SMARCC2;SWI3-like protein;BRG1-associated factor 170;SWI/SNF complex 170 kDa subunit;chromatin remodeling complex BAF170 subunit;mammalian chromatin remodeling complex BRG1-associated factor 170;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SMARCC2-2416H | Recombinant Human SMARCC2, MYC/DDK-tagged | HEK293 | Human | DDK&Myc |
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| SMARCC2-31424TH | Recombinant Human SMARCC2 | Wheat Germ | Human | Non | 1130 amino acids |
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| SMARCC2-1669HCL | Recombinant Human SMARCC2 293 Cell Lysate | HEK293 | Human | Non |
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| SMARCC2-505HF | Recombinant Full Length Human SMARCC2 Protein | In Vitro Cell Free System | Human | Full L. 1130 amino acids |
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| SMARCC2-5684HFL | Recombinant Full Length Human SMARCC2, Flag-tagged | Mammalian Cells | Human | Flag | Full L. |
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| Smarcc2-5962M | Recombinant Mouse Smarcc2 Protein, Myc/DDK-tagged | HEK293 | Mouse | DDK&Myc |
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Involved Pathway
SMARCC2 involved in several pathways and played different roles in them. We selected most pathways SMARCC2 participated on our site, such as Chromatin modifying enzymes,Chromatin organization,Glucocorticoid receptor regulatory network, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMARCC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chromatin modifying enzymes | ATXN7L3,SMYD2A,KDM4A,ASH2L,PHF15,SMARCB1,MBD3,MORF4L1,CSRP2BP,SMARCE1 |
| Glucocorticoid receptor regulatory network | SMARCA4,EGR1,KRT14,CSN2,KRT17,SMARCD1,POU2F1,NR1I3,KRT5,BGLAP |
| Chromatin organization | MTA1,CHD4,EP400,KDM3B,ING4,SMARCC1B,TADA3,SAP30L,KAT6B,PRDM16 |
| Prostate Cancer | CASP9,ARID1A,IGF1,GRB2,PTEN,BCL2,Pdgfa&Pdgfb,SMARCA4,MTOR,SPINK1 |
| RMTs methylate histone arginines | PBRM1L,WDR77,SMARCB1,ACTL6B,PRMT5,COPRS,SMARCD1,SMARCC1,SMARCA2,SMARCD3B |
| TNF-alpha/NF-kB Signaling Pathway | PDCD2,NKIRAS1,COPS3,AKAP8,TNIP1,PAPOLA,PPP1R13L,USP2,LRPPRC,DDX3X |
Protein Function
SMARCC2 has several biochemical functions, for example, contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding,contributes_to RNA polymerase II distal enhancer sequence-specific DNA binding,contributes_to nucleosomal DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMARCC2 itself. We selected most functions SMARCC2 had, and list some proteins which have the same functions with SMARCC2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription coactivator activity | PRMT2,PPARGC1A,TAF1,NFE2,ZEB1,MED26,EDF1,NR5A1,NR1H3,BRD7 |
| contributes_to nucleosomal DNA binding | MBD3,SMARCA4,HDAC1,HDAC2,SMARCE1,ACTB,SMARCC1,CHD4,SMARCB1,MTA2 |
| protein binding | MIIP,ABCC2,IFNAR1,IL13RA1,TRIM29,CORO2B,TTC39B,MYLIPA,TFAP4,APOBEC2B |
| contributes_to RNA polymerase II distal enhancer sequence-specific DNA binding | CHD4,GATAD2B,RBBP4,HDAC1,SMARCA4,SMARCB1,HDAC2,ACTL6A,SMARCE1,MBD3 |
| contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding | RBBP4,MBD3,SMARCB1,SMARCA4,HDAC1,ACTB,MTA2,HDAC2,SMARCE1,ACTL6A |
Interacting Protein
SMARCC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMARCC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMARCC2.
SMARCA4;NCOR1
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References
- Wang, XM; Liao, DW; et al. Monoclonal antibodies reactive with the BAF155 (SMARCC1) and BAF170 (SMARCC2) components of human SWI/SNF-related complexes. HYBRIDOMA 24:55-57(2005).
