SMARCAL1
-
Official Full Name
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 -
Overview
The protein encoded by this gene is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein shows sequence similarity to the E. coli RNA polymerase-binding protein HepA. Mutations in this gene are a cause of Schimke immunoosseous dysplasia (SIOD), an autosomal recessive disorder with the diagnostic features of spondyloepiphyseal dysplasia, renal dysfunction, and T-cell immunodeficiency. -
Synonyms
SMARCAL1;SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1;ATP driven annealing helicase;HARP;HepA related protein;HHARP;SMARCA like Protein 1;Sucrose nonfermenting protein 2 like 1;SWI/SNF Related;SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily A like protein 1;HepA-related protein;SMARCA-like protein 1;ATP-driven annealing helicase;sucrose nonfermenting protein 2-like 1
Recombinant Proteins
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SMARCAL1-2806H | Recombinant Human SMARCAL1, GST-tagged | E.coli | Human | GST | C-term-350aa | |
| SMARCAL1-2674H | Recombinant Human SMARCAL1 protein, His-tagged | E.coli | Human | His | 605-954 aa | |
| SMARCAL1-15600M | Recombinant Mouse SMARCAL1 Protein | Mammalian Cell | Mouse | His |
|
|
| SMARCAL1-5613R | Recombinant Rat SMARCAL1 Protein | Mammalian Cell | Rat | His |
|
|
| SMARCAL1-6789Z | Recombinant Zebrafish SMARCAL1 | Mammalian Cell | Zebrafish | His |
|
|
| SMARCAL1-1646HCL | Recombinant Human SMARCAL1 cell lysate | Human | Non |
|
||
| SMARCAL1-22H | Recombinant Human SMARCAL1 Protein, GST-tagged | Wheat Germ | Human | GST |
|
|
| SMARCAL1-23H | Recombinant Human SMARCAL1 Protein, His-tagged | E.coli | Human | His | Full L. |
|
| SMARCAL1-5272R | Recombinant Rat SMARCAL1 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
|
|
| SMARCAL1-5272R-B | Recombinant Rat SMARCAL1 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
|
||
| SMARCAL1-6779HF | Recombinant Full Length Human SMARCAL1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 954 amino acids |
|
| SMARCAL1-8464M | Recombinant Mouse SMARCAL1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
|
|
| SMARCAL1-8464M-B | Recombinant Mouse SMARCAL1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
|
Involved Pathway
SMARCAL1 involved in several pathways and played different roles in them. We selected most pathways SMARCAL1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SMARCAL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
SMARCAL1 has several biochemical functions, for example, ATP binding,DNA-dependent ATPase activity,annealing helicase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SMARCAL1 itself. We selected most functions SMARCAL1 had, and list some proteins which have the same functions with SMARCAL1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA-dependent ATPase activity | MSH3,ERCC2,CHD8,DMC1,XRCC2,RAD51B,RAD51C,MSH2,SMARCA2,DDX11 |
| ATP binding | RPS6KA3B,CAMK1G,DCLK3,ABCB6A,MYH8,YARS2,KHK,NME2B.2,MAPK12,TDRD12 |
| helicase activity | EIF4A1,CHD8,PL10,HELZ2,RTEL1,CHD6,TDRD9,DHX36,MCM8,DHX57 |
| protein binding | WDHD1,GDF5,CHAMP1,SGTA,ARNTL,PRKAG1,DCTN3,EHMT2,NLGN4X,NEK9 |
| annealing helicase activity | RAD54L,RECQL4,ANXA1,BLM,RECQL,ZRANB3 |
Interacting Protein
SMARCAL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMARCAL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMARCAL1.
RPA2;NS1;ssdna_dt
Resources
Related Services
Related Products
References
