SLC8A1
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Official Full Name
solute carrier family 8 (sodium/calcium exchanger), member 1 -
Synonyms
SLC8A1;solute carrier family 8 (sodium/calcium exchanger), member 1;11068;ENSG00000183023;NCX1;2p23-p22;FLJ37694, FLJ43417, MGC119581, DKFZp779F0871;sodium/calcium exchanger 1;sodium/calcium exchanger 1;Na+/Ca++ exchanger;Na+/Ca2+ exchanger;Na(+)/Ca(2+)-exchange protein 1
Recombinant Proteins
- Mouse
- Chicken
- Rhesus macaque
- Rat
- Human
- Mammalian Cells
- Yeast
- E.coli
- HEK293
- His
- GST
- Avi
- Fc
Involved Pathway
SLC8A1 involved in several pathways and played different roles in them. We selected most pathways SLC8A1 participated on our site, such as Calcium signaling pathway,cGMP-PKG signaling pathway,Cardiac muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC8A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | ITGA2B,JUP,CTNNA3,DSG2,DMD,GJA1,CACNA2D1,DES,TCF7,ITGA7 |
| Olfactory transduction | CAMK2D,ARRB2,OLFR493,CNGA4,OR52J3,OR4D2,OR10A5,OLFR11,OR52B4,GUCY2E |
| cGMP-PKG signaling pathway | ATP1A3,PLCB3,AKT1,IRS1,MAP2K1,ATP2A1,PIK3R1,PIK3CD,PIK3CB,NFATC3 |
| Cardiac muscle contraction | ATP1B3B,ATP1A4,TPM3,CACNB2,COX5B,ATP1B3A,UQCRC2A,COX8C,TNNT2A,CACNG1 |
| Protein digestion and absorption | ACE2,ATP1A1,SLC7A8,KCNK5,CPA3,COL7A1,KCNN4,SLC7A7,ATP1B2,KCNQ1 |
| Hypertrophic cardiomyopathy (HCM) | PRKAA2,CACNB1,CACNA2D2,ACTG1,MYBPC3,CACNG1,ACTB,TPM2,ITGA8,Itga10&Itgb1 |
| Endocrine and other factor-regulated calcium reabsorption | KLK1B22,VDR,KLK1B3,PRKACA,PTH1R,PLCB1,RAB11A,ATP1A1,PRKCA,PRKCB |
| Dilated cardiomyopathy | SGCD,ITGB4,CACNG3,ITGB3,CACNB4,DAG1,LAMA2,ATP2A2,ITGA6,DES |
| Adrenergic signaling in cardiomyocytes | CREM,ACTC1B,ADRa1A,ACTC1A,CACNG1,ADRA1D,ATP1A3B,CACNA1SA,ATP2B1,TNNI3 |
Protein Function
SLC8A1 has several biochemical functions, for example, ankyrin binding,antiporter activity,calcium:sodium antiporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC8A1 itself. We selected most functions SLC8A1 had, and list some proteins which have the same functions with SLC8A1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential | SLC24A6 |
| antiporter activity | CLCN7,SLC25A16,SLC7A7,SLC26A3.2,SLC9A3.2,SLC26A1,SLC7A3,SLC35E4,SLC9A9,SLC9A6B |
| protein binding | PCSK9,EPB41L1,ERC2,IRF8,PEF1,KBTBD6,SILV,OS9,MT1A,TEK |
| calcium:sodium antiporter activity | SLC24A4,SLC8A1B,SLC8A1A,SLC8A2A,SLC8A2B,SLC3A2,SLC8A4B,SLC24A6,SLC8A2,SLC8A4A |
| metal ion binding | ATP2A2A,ZNF672,GNAI1,ROCK2B,ZFP346,SAR1B,PHYH,CYP1C2,CCDC71L,GALNT18A |
| cytoskeletal protein binding | PACSIN3,PACSIN1A,ABI1,EZRB,NF2A,EPB41L4A,PACSIN1,EPB41B,CAPN1,EPB41L5 |
| calmodulin binding | IQGAP3,RGS2,SPTBN1,CAMKK1,INVS,MYO5B,CAMK4,PLCB1,RRAD,MARCKSL1 |
| ankyrin binding | RHCG,SPTBN1,PTBP3,OBSCN,KCNJ11,SCN5A,SLC4A1,RHAG,RHBG,ATP1A1 |
| ion channel binding | KCNB1,FGF12,TRAPPC2,FKBP1B,KCNIP1,RYR2,FAM115C,NEDD4L,ASPH,ABCC9 |
Interacting Protein
SLC8A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC8A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC8A1.
Nanog;Nr0b1;Pou5f1;Zfp42;Znf281;Clstn1
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