SLC3A2
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Official Full Name
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 -
Overview
This gene is a member of the solute carrier family and encodes a cell surface, transmembrane protein. The protein exists as the heavy chain of a heterodimer, covalently bound through di-sulfide bonds to one of several possible light chains. The encoded transporter plays a role in regulation of intracellular calcium levels and transports L-type amino acids. Alternatively spliced transcript variants, encoding different isoforms, have been characterized. -
Synonyms
4F2;CD98;MDU1;4F2HC;4T2HC;NACAE;CD98HC;SLC3A2;4F2 cell-surface antigen heavy chain;heavy chain;CD98 heavy chain;OTTHUMP00000082735;OTTHUMP00000236708;OTTHUMP00000236709;OTTHUMP00000236712;OTTHUMP00000238367;4F2 heavy chain antigen Monoclonal 44D7;lymphocyte activation antigen 4F2 large subunit;antigen defined by Monoclonal 4F2, heavy chain;antigen identified by Monoclonal antibodies 4F2, TRA1.10, TROP4, and T43
Recombinant Proteins
- Human
- Mouse
- Rat
- Mus musculus
- E.coli
- HEK293
- Human Cell
- Wheat Germ
- E.coli expression system
- HEK293T
- Insect Cell
- Baculovirus-Infected Sf9 Cells
- Mammalian cells
- His
- Fc
- His&GST
- Non
- GST
- Myc&DDK
- Flag
- C-hFc & C-His
- His&Fc&Avi
Involved Pathway
SLC3A2 involved in several pathways and played different roles in them. We selected most pathways SLC3A2 participated on our site, such as Protein digestion and absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC3A2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Protein digestion and absorption | FXYD2,ATP1B3,ATP1A3,CELA3B,SLC1A1,PRCP,COL13A1,COL10A1,CPB1,MEP1A |
Protein Function
SLC3A2 has several biochemical functions, for example, calcium:sodium antiporter activity,catalytic activity,cation binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC3A2 itself. We selected most functions SLC3A2 had, and list some proteins which have the same functions with SLC3A2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| double-stranded RNA binding | STRBP,MTDH,ILF3,ZNF346,APTX,MSN,ADARB1,TUBA1B,DHX58,OASL1 |
| catalytic activity | MTHFD1B,OLFM4,ACSS2L,MED16,GOT2B,MDH1AA,DIP2A,PGGT1B,GOT2A,CKMT2B |
| poly(A) RNA binding | TMEM38A,POLR2B,DHX15,DNAJC2,MTHFSD,PLEC,MAGOH,RPS13,WBP11,ZYX |
| neutral amino acid transmembrane transporter activity | SLC7A8,SLC1A5,SLC43A2A,SLC6A19A,SLC43A2B,SLC43A2,SLC6A19B,SLC7A10,SLC15A1B,SLC38A5 |
| protein binding | FAM9A,TNFRSF1B,TTC35,CCDC88A,PSMA7,NDNL2,AHCYL1,CYBRD1,NIPAL1,BLOC1S2 |
| cation binding | SLC3A1,PPM1BA,PPM1AB,PPM1LB,PPM1BB,PPM1DB,SLC3A2B,PPM1LA,PPM1NB,PPM1E |
| calcium:sodium antiporter activity | SLC24A4,SLC24A6,SLC8A2,SLC8A4A,SLC8A1A,SLC8A1,SLC8A2B,SLC8A1B,SLC8A2A,SLC8A4B |
Interacting Protein
SLC3A2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC3A2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC3A2.
EGFR;PTP4A3;ARF6;TSC22D1;PHB2;BRF2;NEK6;GSTK1;PHLDA3;b3xyc5_sollc;15-deoxy-delta(12,14;ere_dna;FN1;cona_canen
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References
- El-Mallawany, NK; Day, N; et al. Differential proteomic analysis of endemic and sporadic Epstein-Barr virus-positive and negative Burkitt lymphoma. EUROPEAN JOURNAL OF CANCER 51:92-100(2015).
- Estrach, S; Lee, SA; et al. CD98hc (SLC3A2) Loss Protects Against Ras-Driven Tumorigenesis by Modulating Integrin-Mediated Mechanotransduction. CANCER RESEARCH 74:6878-6889(2014).
