SKP2
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Official Full Name
S-phase kinase-associated protein 2, E3 ubiquitin protein ligase -
Overview
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas. Alternative splicing of this gene generates three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2011] -
Synonyms
SKP2;S-phase kinase-associated protein 2, E3 ubiquitin protein ligase;p45;FBL1;FLB1;FBXL1;S-phase kinase-associated protein 2;p45skp2;F-box/LRR-repeat protein 1;CDK2/cyclin A-associated protein p45;S-phase kinase-associated protein 2 (p45)
Recombinant Proteins
- Human
- Chicken
- Zebrafish
- Mouse
- E.coli
- Human
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His&T7
- His
- GST
- Non
- DDK&Myc
- His&SUMO
- Flag
Involved Pathway
SKP2 involved in several pathways and played different roles in them. We selected most pathways SKP2 participated on our site, such as FoxO signaling pathway,Cell cycle,Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with SKP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Herpes simplex infection | DDX58,EEF1DA,PML,TNF,HLA-A,IFNA4,PER2,EIF2S1B,TLR2-1,ARNTL |
| Small cell lung cancer | RXRB,TRAF4,LAMA3,CCND1,PTEN,CASP9,TP53,CYCS,ITGAV,BIRC8 |
| Ubiquitin mediated proteolysis | ANAPC13,HERC3,PARK2,UBA7,UBE2W,UBR5,SIAH1A,UBE2D3,SMURF2,CDC23 |
| Pathways in cancer | RELA,RAF1,CDH1,CCNA1,STAT5B,CBLC,AKT1,MMP1,CCNE1,APC |
| Viral carcinogenesis | PKM,HIST1H2BK,GTF2B,MAPK3,CCNA2,HIST3H2BB-PS,PXN,RANBP1,PRKACG,GTF2E1 |
| Epstein-Barr virus infection | HDAC1,IKBKG,NFKBIB,TBPL2,HLA-F,POLR3GL,HDAC4,HLA-DRB4,SYK,ENTPD3 |
| FoxO signaling pathway | SGK2B,BNIP3,PDPK1B,G6PC2,BCL6A,TGFB1A,MAPK10,CDKN1BB,FOXG1A,PRKAG3B |
| Cell cycle | HDAC2,MCM3L,BRCC3,BORA,TGFB2,CETN2,YWHAG1,CENPE,PCM1,PHF8 |
Protein Function
SKP2 has several biochemical functions, for example, identical protein binding,protein binding,contributes_to ubiquitin protein ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SKP2 itself. We selected most functions SKP2 had, and list some proteins which have the same functions with SKP2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | DLX2,FOXM1,HMGB4,SOX13,BEX1,PARD6B,TRIM6,PARP9,SERPINF1,ARF6 |
| identical protein binding | GNPNAT1,SNX8,PFKL,CLDN14,ATXN3,GLE1,RELA,LCP1,SH3GL2,PLEKHH2 |
| contributes_to ubiquitin protein ligase activity | FBXL17,CUL5,FBXL14A,FBXL7,KDM2BA,CUL1A,FBXL3A,UBXN6,FBXL14,MED11 |
Interacting Protein
SKP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SKP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SKP2.
SKP1;CDK2
Resources
Research Area
Ubiquitin-related Molecules in the Akt PathwayE3 Ubiquitin Ligases
Melanoma Biomarkers
Related Services
Related Products
References
- Matsushita, H; Hosoi, A; et al. Cytotoxic T Lymphocytes Block Tumor Growth Both by Lytic Activity and IFN gamma-Dependent Cell-Cycle Arrest. CANCER IMMUNOLOGY RESEARCH 3:26-36(2015).
- Dombrowski, C; Helledie, T; et al. FGFR1 Signaling Stimulates Proliferation of Human Mesenchymal Stem Cells by Inhibiting the Cyclin-Dependent Kinase Inhibitors p21(Waf1) and p27(Kip1). STEM CELLS 31:2724-2736(2013).
