SKAP1
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Official Full Name
src kinase associated phosphoprotein 1 -
Overview
This gene encodes a T cell adaptor protein, a class of intracellular molecules with modular domains capable of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. The encoded protein contains a unique N-terminal region followed by a PH domain and C-terminal SH3 domain. Along with the adhesion and degranulation-promoting adaptor protein, the encoded protein plays a critical role in inside-out signaling by coupling T-cell antigen receptor stimulation to the activation of integrins. -
Synonyms
SKAP1;src kinase associated phosphoprotein 1;SCAP1, src family associated phosphoprotein 1;src kinase-associated phosphoprotein 1;SKAP55;pp55;SKAP-55;src family associated phosphoprotein 1;src family-associated phosphoprotein 1;src kinase-associated phosphoprotein of 55 kDa;SCAP1
Recombinant Proteins
- Human
- Zebrafish
- Rat
- Mouse
- E.coli
- E. coli
- Mammalian Cell
- HEK293
- HEK293T
- GST
- His
- His&T7
- Non
- Myc&DDK
- His&SUMO
- His&Fc&Avi
Involved Pathway
SKAP1 involved in several pathways and played different roles in them. We selected most pathways SKAP1 participated on our site, such as Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SKAP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Rap signaling pathway | FGF6,RAP1B,RASSF5,PLCE1,FGF16,GRIN2B,FGFR1,RASGRP3,P2RY1,SIPA1L1 |
Protein Function
SKAP1 has several biochemical functions, for example, SH2 domain binding,SH3 domain binding,SH3/SH2 adaptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SKAP1 itself. We selected most functions SKAP1 had, and list some proteins which have the same functions with SKAP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein phosphatase binding | SHOC2,VCAN,DRD1,CDH2,TRAF2,JUP,HSF4,PPP1R3G,GNB2L1,ANAPC5 |
| SH2 domain binding | SRC,SH3PXD2B,ARHGAP5,NUP62,NLK,SYP,SIT1,DAG1,MS4A2,LILRB1 |
| protein complex binding | AP2B1,MAPK8IP2,KLHL8,THRA,VDAC1,UQCRC1,CALY,GNB1,GNB2,CDK4 |
| protein kinase binding | ACSL3,AGTR1A,RACGAP1,CDK5RAP2,ILK,HDAC4,DNM2,CNPPD1,PTPRR,NGFRAP1 |
| protein binding | TPRKB,RPL10,NFKBIA,OAS2, Cd79b,BPTF,VCPKMT,TNIK,PINX1,ATG4B |
| SH3/SH2 adaptor activity | SLA,NCK1,SH3BGR,LASP1,BLNK,GAB1,CHN2,GRB2,NCK2,GRAP |
| SH3 domain binding | SH3BP2,PAK3,SH2D2A,CD2AP,ARHGAP17,WAS,DRD4,ADAM19,CCDC6,VASPA |
Interacting Protein
SKAP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SKAP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SKAP1.
FYB;BLCAP;FAM102A;PRAM1;SH2D4A;SH2D4A
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References
- Zhong, J; Kim, MS; et al. TSLP Signaling Network Revealed by SILAC-Based Phosphoproteomics. MOLECULAR & CELLULAR PROTEOMICS 11:-(2012).
- Roberts, W; Magwenzi, S; et al. Thrombospondin-1 induces platelet activation through CD36-dependent inhibition of the cAMP/protein kinase A signaling cascade. BLOOD 116:4297-4306(2010).
