SHMT1
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Official Full Name
serine hydroxymethyltransferase 1 (soluble) -
Overview
This gene encodes the cellular form of serine hydroxymethyltransferase, a pyridoxal phosphate-containing enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one carbon units for synthesis of methionine, thymidylate, and purines in the cytoplasm. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternative splicing of this gene results in 2 transcript variants encoding 2 different isoforms. Additional transcript variants have been described, but their biological validity has not been determined. -
Synonyms
SHMT1;serine hydroxymethyltransferase 1 (soluble);serine hydroxymethyltransferase, cytosolic;14 kDa protein;CSHMT;cytoplasmic serine hydroxymethyltransferase;MGC15229;MGC24556;SHMT;serine methylase;glycine hydroxymethyltransferase
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Rhesus macaque
- E.coli
- Mammalian Cells
- Human
- HEK293
- GST
- His
- Non
- DDK
- Myc
- Avi
- Fc
Involved Pathway
SHMT1 involved in several pathways and played different roles in them. We selected most pathways SHMT1 participated on our site, such as Glycine, serine and threonine metabolism,Cyanoamino acid metabolism,Glyoxylate and dicarboxylate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with SHMT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glyoxylate and dicarboxylate metabolism | CAT,AMT,CS,GLULA,GRHPRA,AGXTB,DHDPSL,GRHPRB,PCCB,HOGA1 |
| One carbon pool by folate | AMT,MTFMT,MTR,ALDH1L2,MTHFD1L,ATIC,MTHFD1,DHFRL1,MTHFD2,FTCD |
| Metabolic pathways | RRM2B,ATP6V0A4,CHSY1,PLA2G2D,ALDH1A1,CHKB,POLR2F,B4GALNT1,NT5C1B-RDH14,GCSH |
| Carbon metabolism | FH1,PDHA1B,IDH3B,DLD,PKMA,PGAM1B,PGK2,SDHB,TKTB,MUT |
| Biosynthesis of amino acids | ALDOAB,PRPS1,THA1,GLULA,PGAM1B,CS,IDH2,GOT2,ENO1,TPI1 |
| Glycine, serine and threonine metabolism | PHGDH,ALDH7A1,AOC3,PSAT1,MAOA,GATM,GCSHA,GAMT,CBSB,SDSL |
| Cyanoamino acid metabolism | GGT7,GGT5,GGT1A,GGT1,SHMT2,GBA3,GGT6,GGT5A |
Protein Function
SHMT1 has several biochemical functions, for example, L-allo-threonine aldolase activity,glycine hydroxymethyltransferase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SHMT1 itself. We selected most functions SHMT1 had, and list some proteins which have the same functions with SHMT1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| glycine hydroxymethyltransferase activity | SHMT2 |
| protein homodimerization activity | KCNE2,ADD2,DMRTC1B,PDGFRA,TOX3,PAFAH1B2,MASP1,PARK7,BARD1,ASNSD1 |
| L-allo-threonine aldolase activity | SHMT2,THA1 |
| protein binding | ELMO3,TOP1,POLH,INTS5,AAK1,RSPH1,GNAI3,FDX1L,NTHL1,OCLN |
| pyridoxal phosphate binding | GOT2,DDC,CBSA,AGXT2,SDSL,HINT2,MOSC2,SRR,CCBL2,GOT1 |
| serine binding | THNSL2,GRM7 |
Interacting Protein
SHMT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SHMT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SHMT1.
SULT1A3;MAPK9;DLEU1;DEDD;PRSS23;PIM1;MAP1LC3B
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