SHARPIN
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Official Full Name
SHANK-associated RH domain interactor -
Synonyms
SHARPIN;SHANK-associated RH domain interactor;DKFZP434N1923;SIPL1;hSIPL1;Shank associated RH domain interacting protein;SHANK associated RH domain interactor;Shank interacting protein like 1;Shank-associated RH domain-interacting protein;Shank-interacting protein-like 1;SHRPN_HUMAN
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- Mammalian Cell
- HEK293T
- HEK293
- GST
- His
- Non
- Myc&DDK
- N-His&C-Myc
- His&Fc&Avi
Involved Pathway
SHARPIN involved in several pathways and played different roles in them. We selected most pathways SHARPIN participated on our site, such as Death Receptor Signalling,Regulation of TNFR1 signaling,Signal Transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with SHARPIN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Regulation of TNFR1 signaling | OTULIN,OTUD7B,SHRPRBCK1R,FAM105B,OTULINB,RNF31,CLIP3,USP2,TAX1BP1B,RBCK1 |
| TNFR1-induced NFkappaB signaling pathway | USP2,SHRPRBCK1R,OTUD7B,RNF31,USP4 |
| Death Receptor Signalling | USP4,TAB1,CLIP3,TAX1BP1B,FAM105B,OTULIN,OTULINB,OTUD7B,USP2,TAX1BP1 |
| TNF signaling | SHRPRBCK1R,CLIP3,TAX1BP1,USP2,OTULINB,OTULIN,OTUD7B,RBCK1,FAM105B,TAX1BP1B |
| Signal Transduction | IFT52,FMNL1,ROR2,RLBP1B,CSHL1,ARHGAP20,ZFPM2B,FAM105B,CDC73,MOB1BA |
Protein Function
SHARPIN has several biochemical functions, for example, identical protein binding,polyubiquitin binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SHARPIN itself. We selected most functions SHARPIN had, and list some proteins which have the same functions with SHARPIN. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein complex binding | ST13,CTSL2,ATG101,FLCN,CCNE1,ITGB1BP1,PTK2B,TAPBPL,VHLL,Apba1 |
| polyubiquitin binding | EPS15,PSMD4B,FAM175A,DZIP3,PSMD4,DNAJB2,RAD23B,PSMD4A,BRCC3,RAD18 |
| identical protein binding | NDC80,ACTB,EDC3,WRNIP1,ATG101,TRA@,COL1A2,TNF,TRAF6,VWA1 |
| zinc ion binding | KAT6A,RNF130,VPS29,USP16,MMP12,MECR,ZDHHC18,DNLZ,TNFAIP3,ADH8B |
| protein binding | ROS1,ATPAF1,TSSK4,SLC30A2,ZFC3H1,FOXP1,NR2F1,BRPF1,FOXRED2,APOL1 |
Interacting Protein
SHARPIN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SHARPIN here. Most of them are supplied by our site. Hope this information will be useful for your research of SHARPIN.
ITGA2;ITGA5;RNF31;TNF;IKBKG;TNFAIP3;IL1A
Resources
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References
- Matsumoto, ML; Dong, KC; et al. Engineering and Structural Characterization of a Linear Polyubiquitin-Specific Antibody. JOURNAL OF MOLECULAR BIOLOGY 418:134-144(2012).
- Queisser, MA; Dada, LA; et al. HOIL-1L Functions as the PKC zeta Ubiquitin Ligase to Promote Lung Tumor Growth. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 190:688-698(2014).
- Renninger, ML; Seymour, RE; et al. Anti-IL5 decreases the number of eosinophils but not the severity of dermatitis in Sharpin-deficient mice. EXPERIMENTAL DERMATOLOGY 19:252-258(2010).
